Linked Life Data

16467258

Source:http://linkedlifedata.com/resource/pubmed/id/16467258

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2006-2-9
pubmed:abstractText
Levels of estrogen within the male reproductive tract are higher than in the general circulation and the aromatase enzyme is expressed in the adult testis. Estrogens such as estradiol (E2) modify cell function by binding to high-affinity estrogen receptors (ER). Two subtypes (ERalpha and ERbeta) have been identified. Studies in animals have shown that over- or underexposure to estrogens can have an impact on testis function. For example, mice with targeted disruption of the aromatase cyp19 gene become infertile because round spermatids fail to differentiate normally. In rodents, ERalpha is expressed in Leydig cells; ERalpha mRNA and protein are not detectable in testes from humans or primates. High levels of expression of ERalpha occur in the efferent ductules in rodents, primates, and the human. ERbeta protein has been immunolocalized to all somatic cells and to some germ cells in these same species. Messenger RNAs for splice variant isoforms of human ERbeta are expressed in human testes. Homologues of the ERbeta2 variant have been cloned from primates; this isoform does not exist in rodents and does not bind E2. Full-length ERbeta protein (ERbeta1) and ERbeta2 have differential patterns of expression in human testes. In conclusion, although estrogens are synthesized in the testis and it has been suggested that E2 may function as a germ cell survival factor, the mechanisms by which estrogens influence male fertility remain uncertain and rodents may be poor models in which to examine this.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0077-8923
pubmed:author
pubmed:issnType
Print
pubmed:volume
1061
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
65-76
pubmed:dateRevised
2008-9-17
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Estrogens in testis biology.
pubmed:affiliation
MRC Human Reproductive Sciences Unit, The Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, Scotland, UK.
pubmed:publicationType
Journal Article, Review