16467159

Source:http://linkedlifedata.com/resource/pubmed/id/16467159

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0012854, umls-concept:C0032550, umls-concept:C0150369, umls-concept:C0178499, umls-concept:C0260249, umls-concept:C0439851, umls-concept:C0439852, umls-concept:C1552596, umls-concept:C1626935, umls-concept:C1883709, umls-concept:C1947931
pubmed:issue	7
pubmed:dateCreated	2006-2-15
pubmed:abstractText	The nucleotide 5'-dGMP and polynucleotide poly(dGdC).poly(dGdC) have been irradiated by using a 200-fs, 200-nm laser pulses and spectrally characterized by using time-resolved infrared spectroscopy. Under the experimental conditions, 200-nm excitation generates both electronic excited states and radical cations through photoionization; the former decay rapidly to vibrationally hot ground state. By using infrared signatures we have been able to follow these processes, and at time scales of >1 ns we observe an infrared marker band at 1,702 cm(-1) within both 5'-dGMP and the polynucleotide assigned to a photoionized product of guanine. This transient has also been reproduced through indirect chemistry through the reaction with photogenerated carbonate radical with 5'-dGMP. The ability to use time-resolved infrared spectroscopy in this way paves the way for developing solution-phase studies to investigate both direct and indirect radiation chemistry of DNA.
pubmed:commentsCorrections	http://linkedlifedata.com/resource/pubmed/commentcorrection/16467159-11641491, http://linkedlifedata.com/resource/pubmed/commentcorrection/16467159-12926943, http://linkedlifedata.com/resource/pubmed/commentcorrection/16467159-14658632, http://linkedlifedata.com/resource/pubmed/commentcorrection/16467159-15080719, http://linkedlifedata.com/resource/pubmed/commentcorrection/16467159-15381780, http://linkedlifedata.com/resource/pubmed/commentcorrection/16467159-15738421, http://linkedlifedata.com/resource/pubmed/commentcorrection/16467159-15901332, http://linkedlifedata.com/resource/pubmed/commentcorrection/16467159-16013075, http://linkedlifedata.com/resource/pubmed/commentcorrection/16467159-7568405, http://linkedlifedata.com/resource/pubmed/commentcorrection/16467159-7983439, http://linkedlifedata.com/resource/pubmed/commentcorrection/16467159-8265784, http://linkedlifedata.com/resource/pubmed/commentcorrection/16467159-8396268, http://linkedlifedata.com/resource/pubmed/commentcorrection/16467159-9776756
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/7505876
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/DNA, http://linkedlifedata.com/resource/pubmed/chemical/Polydeoxyribonucleotides, http://linkedlifedata.com/resource/pubmed/chemical/poly(dG).poly(dC)
pubmed:status	MEDLINE
pubmed:month	Feb
pubmed:issn	0027-8424
pubmed:author	pubmed-author:CowanAlexander JAJ, pubmed-author:GeorgeMichael WMW, pubmed-author:KuimovaMarina KMK, pubmed-author:MatousekPavelP, pubmed-author:ParkerAnthony WAW, pubmed-author:SunXue ZhongXZ, pubmed-author:TowrieMichaelM
pubmed:issnType	Print
pubmed:day	14
pubmed:volume	103
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	2150-3
pubmed:dateRevised	2009-11-18
pubmed:meshHeading	pubmed-meshheading:16467159-DNA, pubmed-meshheading:16467159-DNA Damage, pubmed-meshheading:16467159-Lasers, pubmed-meshheading:16467159-Polydeoxyribonucleotides, pubmed-meshheading:16467159-Spectroscopy, Fourier Transform Infrared
pubmed:year	2006
pubmed:articleTitle	Monitoring the direct and indirect damage of DNA bases and polynucleotides by using time-resolved infrared spectroscopy.
pubmed:affiliation	School of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, United Kingdom.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't, Evaluation Studies