Linked Life Data

16466918

Source:http://linkedlifedata.com/resource/pubmed/id/16466918

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
pubmed:issue
3
pubmed:dateCreated
2006-3-13
pubmed:abstractText
Several transcription factors have been identified that control the differentiation of osteoblasts; however, relatively little is known about the signaling pathways involved in regulating the differentiation process. Recently, the canonical Wnt-beta-catenin pathway has been implicated in osteoblastogenesis. This review focuses on the role of the canonical Wnt-beta-catenin pathway during embryonic development, where it is required for the differentiation of osteoblasts from a precursor that is shared with the chondrocyte lineage and the requirement of this pathway during postnatal life in bone homeostasis. The recent findings covered in this review are major advances in our understanding of skeletal development and promise new therapeutic avenues for tissue engineering and treatment of osteoporosis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0962-8924
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
151-8
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
A Wnt canon orchestrating osteoblastogenesis.
pubmed:affiliation
Institute of Molecular Pathology, Dr. Bohr-Gasse 7, 1030 Vienna, Austria. hartmann@imp.univie.ac.at
pubmed:publicationType
Journal Article, Review