| pubmed-article:1646654 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1646654 | lifeskim:mentions | umls-concept:C0950124 | lld:lifeskim |
| pubmed-article:1646654 | lifeskim:mentions | umls-concept:C0348026 | lld:lifeskim |
| pubmed-article:1646654 | lifeskim:mentions | umls-concept:C1744620 | lld:lifeskim |
| pubmed-article:1646654 | lifeskim:mentions | umls-concept:C0162788 | lld:lifeskim |
| pubmed-article:1646654 | lifeskim:mentions | umls-concept:C0220901 | lld:lifeskim |
| pubmed-article:1646654 | lifeskim:mentions | umls-concept:C0205195 | lld:lifeskim |
| pubmed-article:1646654 | lifeskim:mentions | umls-concept:C1522609 | lld:lifeskim |
| pubmed-article:1646654 | lifeskim:mentions | umls-concept:C1554112 | lld:lifeskim |
| pubmed-article:1646654 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:1646654 | pubmed:dateCreated | 1991-7-23 | lld:pubmed |
| pubmed-article:1646654 | pubmed:abstractText | A combined diagnostic system for human papilloma virus (HPV) infections comprising the Papanicolaou test and in-situ hybridization assay was evaluated. Cervical smears from 259 women obtained with a "Cytobrush" were screened. Human papilloma virus genotypes 6/11, 16/18, 31/35/51 were detected by biotin in-situ hybridization in conjunction with a streptavidin-alkaline phosphatase detection complex. The diagnostic sensitivity of this assay was tested by human papilloma virus-DNA-positive human cervical carcinoma cell lines. According to the cytological (Bethesda system) and colposcopical criteria a random control group (n = 80) and prevention (n = 179) were chosen. Compared with Papanicolaou tests the frequency of human papilloma virus-DNA-positive cervices rose with the severity of cell abnormalities. The detection rate of human papilloma viruses-16/18 and human papilloma viruses-31/35/51 and of concomitant infections with human papilloma viruses-6/11 and human papilloma viruses-16/18 and/or human papilloma viruses-31/35/51 increased with the severity of cell dysplasia, whereas the rate of human papilloma virus-6/11 DNAs decreased. The incidence of oncogenic human papilloma virus types 16/18 and 31/35/51 rose with the age of the patients. A follow-up study by Papanicolaou tests of patients with mild (slight) and moderate dysplasias six months after human papilloma virus-DNA-hybridization indicates that human papilloma virus-16/18 DNA-positive lesions are more likely to persist or to progress than human papilloma virus-6/11 DNA-positive cell changes. Human papilloma virus-31/35/51 DNA-positive cell smears exhibited persistent behaviour. Our findings demonstrate that the Papanicolaou test combined with in-situ hybridization is suitable for early diagnosis and prevention of intraepithelial neoplasias and carcinomas of the uterine cervix. | lld:pubmed |
| pubmed-article:1646654 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1646654 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1646654 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1646654 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1646654 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:1646654 | pubmed:issn | 0939-4974 | lld:pubmed |
| pubmed-article:1646654 | pubmed:author | pubmed-author:KramarRR | lld:pubmed |
| pubmed-article:1646654 | pubmed:author | pubmed-author:KubistaEE | lld:pubmed |
| pubmed-article:1646654 | pubmed:author | pubmed-author:SchurzBB | lld:pubmed |
| pubmed-article:1646654 | pubmed:author | pubmed-author:CzerwenkaK... | lld:pubmed |
| pubmed-article:1646654 | pubmed:author | pubmed-author:SchönH JHJ | lld:pubmed |
| pubmed-article:1646654 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1646654 | pubmed:volume | 29 | lld:pubmed |
| pubmed-article:1646654 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1646654 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1646654 | pubmed:pagination | 131-8 | lld:pubmed |
| pubmed-article:1646654 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:1646654 | pubmed:meshHeading | pubmed-meshheading:1646654-... | lld:pubmed |
| pubmed-article:1646654 | pubmed:meshHeading | pubmed-meshheading:1646654-... | lld:pubmed |
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| pubmed-article:1646654 | pubmed:meshHeading | pubmed-meshheading:1646654-... | lld:pubmed |
| pubmed-article:1646654 | pubmed:meshHeading | pubmed-meshheading:1646654-... | lld:pubmed |
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| pubmed-article:1646654 | pubmed:meshHeading | pubmed-meshheading:1646654-... | lld:pubmed |
| pubmed-article:1646654 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1646654 | pubmed:articleTitle | Papanicolaou test and enzyme-linked in-situ hybridization. A combined diagnostic system for papilloma virus infections with high prognostic value. | lld:pubmed |
| pubmed-article:1646654 | pubmed:affiliation | Institut für Medizinische Chemie, Universität Wien. | lld:pubmed |
| pubmed-article:1646654 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1646654 | lld:pubmed |
