1646645

Source:http://linkedlifedata.com/resource/pubmed/id/1646645

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0001455, umls-concept:C0596019, umls-concept:C0678640, umls-concept:C0806036, umls-concept:C1515877, umls-concept:C1655052, umls-concept:C1879547
pubmed:issue	3
pubmed:dateCreated	1991-7-19
pubmed:abstractText	The role of cAMP in regulation of intracellular pH in the confluent LLC-PK1 cells was investigated. DibutyrylcAMP and forskolin induce intracellular acidification. This acidification is inhibited by DIDS and ethacrynic acid, inhibitors of Na(+)-independent Cl-/HCO3- exchange, and by removal of extracellular Cl-. In addition, Bt2 cAMP causes Cl- entry into LLC-PK1 cells. These results suggest that cAMP activates Cl- transport, namely Na(+)-independent Cl-/HCO3- exchange, which participates in pHi regulation.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0217513
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/4,4'-Diisothiocyanostilbene-2,2'-Dis..., http://linkedlifedata.com/resource/pubmed/chemical/4-Acetamido-4'-isothiocyanatostilben..., http://linkedlifedata.com/resource/pubmed/chemical/Amiloride, http://linkedlifedata.com/resource/pubmed/chemical/Bicarbonates, http://linkedlifedata.com/resource/pubmed/chemical/Bucladesine, http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Chloride-Bicarbonate Antiporters, http://linkedlifedata.com/resource/pubmed/chemical/Chlorides, http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP, http://linkedlifedata.com/resource/pubmed/chemical/Ethacrynic Acid, http://linkedlifedata.com/resource/pubmed/chemical/Forskolin, http://linkedlifedata.com/resource/pubmed/chemical/Furosemide, http://linkedlifedata.com/resource/pubmed/chemical/Trinitrobenzenesulfonic Acid
pubmed:status	MEDLINE
pubmed:month	May
pubmed:issn	0006-3002
pubmed:author	pubmed-author:AnzaiMM, pubmed-author:HaradaHH, pubmed-author:KanaiYY, pubmed-author:SuketaYY
pubmed:issnType	Print
pubmed:day	17
pubmed:volume	1092
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	404-7
pubmed:dateRevised	2003-11-14
pubmed:meshHeading	pubmed-meshheading:1646645-4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid, pubmed-meshheading:1646645-4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid, pubmed-meshheading:1646645-Amiloride, pubmed-meshheading:1646645-Animals, pubmed-meshheading:1646645-Bicarbonates, pubmed-meshheading:1646645-Bucladesine, pubmed-meshheading:1646645-Carrier Proteins, pubmed-meshheading:1646645-Cell Line, pubmed-meshheading:1646645-Chloride-Bicarbonate Antiporters, pubmed-meshheading:1646645-Chlorides, pubmed-meshheading:1646645-Cyclic AMP, pubmed-meshheading:1646645-Epithelial Cells, pubmed-meshheading:1646645-Epithelium, pubmed-meshheading:1646645-Ethacrynic Acid, pubmed-meshheading:1646645-Forskolin, pubmed-meshheading:1646645-Furosemide, pubmed-meshheading:1646645-Hydrogen-Ion Concentration, pubmed-meshheading:1646645-Intracellular Fluid, pubmed-meshheading:1646645-Kidney, pubmed-meshheading:1646645-Swine, pubmed-meshheading:1646645-Time Factors, pubmed-meshheading:1646645-Trinitrobenzenesulfonic Acid
pubmed:year	1991
pubmed:articleTitle	cAMP activates Cl-/HCO-3 exchange for regulation of intracellular pH in renal epithelial cells.
pubmed:affiliation	Department of Environmental Biochemistry and Toxicology, University of Shizuoka, School of Pharmaceutical Sciences, Japan.
pubmed:publicationType	Journal Article