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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1975-6-25
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pubmed:abstractText |
Two out of seven meningiomas tested in early cell cultures by indirect immunofluorescence staining showed simian virus 40 (SV40)-related tumor (T) antigen. In one tumor 90% of the cells were positive. An additional SV40-related antigen (U) was found in 10% of cells of a third tumor. These findings indicate that the meningioma cells showing a positive reaction are transformed by a papova virus that has at least partly the same antigenic properties as SV40 virus. SV40-related viral capsid (V) antigen was absent in all the meningiomas tested. No virus infectious for African green monkey kidney (AGMK) cells could be isolated. The tumors positive for T and U antigens showed the chromosome aberration typical for human meningiomas, i.e., the loss of one chromosome, G-22. The T-antigen-positive tumors showed further hypodiploidization. Experiments to rescue virus from the T-antigen-positive tumors showed further hypodiploidization. Experiments to rescue virus from the T-antigen-positive meningioma cells were performed: fusion of cells pretreated with 8-azaguanine with cells premissive for SV40 led to a low percentage (0.01-0.05%) of V-antigen-positive nuclei in heterokaryon cultures. On the basis of these results, the possibility of a correlation between the meningioma, a relatively common intracranial tumor in man, and an SV40-related papova virus must be considered. It remains to be shown whether this virus is a causative agent for human meningiomas.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/164660-13772379,
http://linkedlifedata.com/resource/pubmed/commentcorrection/164660-13774265,
http://linkedlifedata.com/resource/pubmed/commentcorrection/164660-14002574,
http://linkedlifedata.com/resource/pubmed/commentcorrection/164660-14051836,
http://linkedlifedata.com/resource/pubmed/commentcorrection/164660-14476249,
http://linkedlifedata.com/resource/pubmed/commentcorrection/164660-4104714,
http://linkedlifedata.com/resource/pubmed/commentcorrection/164660-4104715,
http://linkedlifedata.com/resource/pubmed/commentcorrection/164660-4112624,
http://linkedlifedata.com/resource/pubmed/commentcorrection/164660-4112733,
http://linkedlifedata.com/resource/pubmed/commentcorrection/164660-4114323,
http://linkedlifedata.com/resource/pubmed/commentcorrection/164660-4318033,
http://linkedlifedata.com/resource/pubmed/commentcorrection/164660-4329396,
http://linkedlifedata.com/resource/pubmed/commentcorrection/164660-4333082,
http://linkedlifedata.com/resource/pubmed/commentcorrection/164660-4348302,
http://linkedlifedata.com/resource/pubmed/commentcorrection/164660-4365941,
http://linkedlifedata.com/resource/pubmed/commentcorrection/164660-4920091,
http://linkedlifedata.com/resource/pubmed/commentcorrection/164660-5423930,
http://linkedlifedata.com/resource/pubmed/commentcorrection/164660-6050684
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
72
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
609-13
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:164660-Adult,
pubmed-meshheading:164660-Antigens, Neoplasm,
pubmed-meshheading:164660-Antigens, Viral,
pubmed-meshheading:164660-Cell Line,
pubmed-meshheading:164660-Chromosome Aberrations,
pubmed-meshheading:164660-Chromosomes, Human, 21-22 and Y,
pubmed-meshheading:164660-Female,
pubmed-meshheading:164660-Fluorescent Antibody Technique,
pubmed-meshheading:164660-Humans,
pubmed-meshheading:164660-Karyotyping,
pubmed-meshheading:164660-Kidney,
pubmed-meshheading:164660-Male,
pubmed-meshheading:164660-Meningioma,
pubmed-meshheading:164660-Middle Aged,
pubmed-meshheading:164660-Mosaicism,
pubmed-meshheading:164660-Simian virus 40
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pubmed:year |
1975
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pubmed:articleTitle |
Simian virus 40-related antigens in three human meningiomas with defined chromosome loss.
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pubmed:publicationType |
Journal Article
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