Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
16
pubmed:dateCreated
2006-4-17
pubmed:abstractText
We have sequenced 36,641 expressed sequence tags from laser capture microdissected adult mouse gastric and small intestinal epithelial progenitors, obtaining 4031 and 3324 unique transcripts, respectively. Using Gene Ontology (GO) terms, each data set was compared with cDNA libraries from intact adult stomach and small intestine. Genes in GO categories enriched in progenitors were filtered against genes in GO categories represented in hematopoietic, neural, and embryonic stem cell transcriptomes and mapped onto transcription factor networks, plus canonical signal transduction and metabolic pathways. Wnt/beta-catenin, phosphoinositide-3/Akt kinase, insulin-like growth factor-1, vascular endothelial growth factor, integrin, and gamma-aminobutyric acid receptor signaling cascades, plus glycerolipid, fatty acid, and amino acid metabolic pathways are among those prominently represented in adult gut progenitors. The results reveal shared as well as distinctive features of adult gut stem cells when compared with other stem cell populations.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0021-9258
pubmed:author
pubmed:issnType
Print
pubmed:day
21
pubmed:volume
281
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
11292-300
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:16464855-Animals, pubmed-meshheading:16464855-Computational Biology, pubmed-meshheading:16464855-DNA, Complementary, pubmed-meshheading:16464855-Epithelial Cells, pubmed-meshheading:16464855-Epithelium, pubmed-meshheading:16464855-Expressed Sequence Tags, pubmed-meshheading:16464855-Gastric Mucosa, pubmed-meshheading:16464855-Gene Library, pubmed-meshheading:16464855-Genome, pubmed-meshheading:16464855-Hematopoietic Stem Cells, pubmed-meshheading:16464855-Immunohistochemistry, pubmed-meshheading:16464855-Intestine, Small, pubmed-meshheading:16464855-Intestines, pubmed-meshheading:16464855-Lasers, pubmed-meshheading:16464855-Mice, pubmed-meshheading:16464855-Models, Biological, pubmed-meshheading:16464855-Neurons, pubmed-meshheading:16464855-RNA, Messenger, pubmed-meshheading:16464855-Signal Transduction, pubmed-meshheading:16464855-Software, pubmed-meshheading:16464855-Stem Cells, pubmed-meshheading:16464855-Stomach, pubmed-meshheading:16464855-Transcription Factors
pubmed:year
2006
pubmed:articleTitle
Molecular properties of adult mouse gastric and intestinal epithelial progenitors in their niches.
pubmed:affiliation
Center for Genome Sciences, Washington University, St. Louis, Missouri 63108, USA.
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural