|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
16
|
|
pubmed:dateCreated |
2006-4-17
|
|
pubmed:abstractText |
Bax and Bak comprise the mitochondrial gateway for apoptosis induced by diverse stimuli. Loss of both bax and bak is necessary to block cell death induced by such stimuli, indicating a great degree of functional overlap between Bax and Bak. Apoptosis is the major intrinsic pathway that limits the oncogenic potential of Myc. Using a switchable mouse model of Myc-induced apoptosis in pancreatic beta cells, we have shown that Myc induces apoptosis in vivo exclusively through Bax but not Bak. Furthermore, blockade of Myc-induced apoptosis by the inactivation of Bax, but not Bak, eliminates all restraints to the oncogenic potential of Myc, allowing the rapid and synchronous progression of invasive, angiogenic tumors.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
0021-9258
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
21
|
|
pubmed:volume |
281
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
10890-5
|
|
pubmed:dateRevised |
2007-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:16464852-Animals,
pubmed-meshheading:16464852-Antineoplastic Agents, Hormonal,
pubmed-meshheading:16464852-Apoptosis,
pubmed-meshheading:16464852-Cell Proliferation,
pubmed-meshheading:16464852-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:16464852-Glucagon,
pubmed-meshheading:16464852-Immunohistochemistry,
pubmed-meshheading:16464852-In Situ Nick-End Labeling,
pubmed-meshheading:16464852-Insulin-Secreting Cells,
pubmed-meshheading:16464852-Mice,
pubmed-meshheading:16464852-Mice, Transgenic,
pubmed-meshheading:16464852-Microscopy, Confocal,
pubmed-meshheading:16464852-Microscopy, Fluorescence,
pubmed-meshheading:16464852-Neoplasm Invasiveness,
pubmed-meshheading:16464852-Neoplasms,
pubmed-meshheading:16464852-Neoplasms, Experimental,
pubmed-meshheading:16464852-Neovascularization, Pathologic,
pubmed-meshheading:16464852-Pancreas,
pubmed-meshheading:16464852-Proto-Oncogene Proteins c-myc,
pubmed-meshheading:16464852-Tamoxifen,
pubmed-meshheading:16464852-bcl-2 Homologous Antagonist-Killer Protein,
pubmed-meshheading:16464852-bcl-2-Associated X Protein
|
|
pubmed:year |
2006
|
|
pubmed:articleTitle |
Specific requirement for Bax, not Bak, in Myc-induced apoptosis and tumor suppression in vivo.
|
|
pubmed:affiliation |
Cancer Research Institute and Department of Cellular and Molecular Pharmacology, Comprehensive Cancer Center, University of California at San Francisco, San Francisco, California 94143-0875, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|
