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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2006-4-24
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pubmed:abstractText |
Treatment of 2-bromoacetylbenzofuran with 1H-benzotriazole afforded 1-(benzofuran-2-yl)-2-(benzotriazol-1-yl)ethanone which reacted with phenylisothiocyanate to give the corresponding thioacetanilide derivatives. Treatment of the latter ethanone and thioacetanilide derivatives with hydrazonoyl chlorides afforded the corresponding pyrazole and 1,3,4-thiadiazole derivatives. The thioacetanilide derivative reacted with alpha-haloketones and alpha-halodiketones to afford thiophene and thiazole derivatives, respectively. The newly synthesized compounds were found to possess anticonvulsant and anti-inflammatory activities with the same mechanism of action of selective COX-2 inhibitors.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0968-0896
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3672-80
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pubmed:meshHeading |
pubmed-meshheading:16464601-Animals,
pubmed-meshheading:16464601-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:16464601-Anticonvulsants,
pubmed-meshheading:16464601-Benzofurans,
pubmed-meshheading:16464601-Cyclooxygenase 2 Inhibitors,
pubmed-meshheading:16464601-Drug Evaluation, Preclinical,
pubmed-meshheading:16464601-Heterocyclic Compounds,
pubmed-meshheading:16464601-Mice,
pubmed-meshheading:16464601-Molecular Structure,
pubmed-meshheading:16464601-Stereoisomerism,
pubmed-meshheading:16464601-Structure-Activity Relationship,
pubmed-meshheading:16464601-Triazoles
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pubmed:year |
2006
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pubmed:articleTitle |
Synthesis, anticonvulsant, and anti-inflammatory evaluation of some new benzotriazole and benzofuran-based heterocycles.
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pubmed:affiliation |
Chemistry Department, Faculty of Science, Cairo University, Giza 12613, Egypt. dr_dawood@yahoo.com
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pubmed:publicationType |
Journal Article
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