Linked Life Data

16463684

Source:http://linkedlifedata.com/resource/pubmed/id/16463684

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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2006-2-8
pubmed:abstractText
The measurement of coronary flow velocity reserve (CFVR) by transthoracic Doppler echocardiography (TTDE) with invasive intracoronary Doppler flow wire technique (ICD) was validated and the pathological factors which influence CFVR in patients with angiographically normal coronary arteries were analyzed. CFVR was determined successfully in left anterior descending artery (LAD) in 37 of 40 patients with angiographically normal coronary arteries (men 22, women 15, age 20-75 years, mean age 54 +/- 12 years). Coronary flow velocity was measured in the distal LAD by TTDE with contrast enhancement at baseline and during intravenous adenosine infusion of 140 microg/kg per min within 48 h after ICD technique. Average peak velocity at baseline (APVb), average peak velocity during hyperemia (APVh) and CFVR determined from TTDE were correlated closely with those from ICD measurements (APVb: y = 0.64x + 5.04, r = 0.86, P < 0.001; APVh: y = 0.63x + 14.36, r = 0.82, P < 0.001; CFVR: y = 0.65x + 0.92, r = 0.88, P < 0.001). For CFVR measurements, the mean differences between TTDE and ICD methods were 0.12 +/- 0.39. CFVR in patients with history of hypertension was significantly lower than that in patients without history of hypertension (P < 0.05). Intravascular ultrasound (IVUS) was performed in 34 patients. Plaque formation was found in LAD by IVUS in 17 (50%) patients. No significant difference in CFVR was found between the patients without plaque formation (3.11 +/- 0.49) and those with plaque formation (2.76 +/- 0.53, P = 0.056). It is suggested that TTDE with contrast enhancement provides reliable measurement of APV and CFVR in the distal LAD. The early stage of atherosclerosis could be detected by IVUS, which may be normal in angiography. CFVR is impaired in patients with history of hypertension compared with that in patients without history of hypertension.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1672-0733
pubmed:author
pubmed:issnType
Print
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
590-3, 614
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Assessment of coronary flow velocity reserve by noninvasive transthoracic Doppler echocardiography in patients with angiographically normal coronary arteries.
pubmed:affiliation
Anzhen Hospital, The Capital University of Medical Sciences, Beijing 100029, China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't