Source:http://linkedlifedata.com/resource/pubmed/id/16462760
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
28
|
| pubmed:dateCreated |
2006-6-30
|
| pubmed:databankReference | |
| pubmed:abstractText |
The RASSF8 gene, which maps close to the KRAS2 gene, contains a RAS-associated domain and encodes a protein that is evolutionarily conserved from fish to humans. Analysis of the RASSF8 transcript revealed a complex expression pattern of 5'-UTR mRNA isoforms in normal lung and in lung adenocarcinomas (ADCAs), with no apparent differences. However, RASSF8 gene transcript levels were approximately seven-fold-lower in lung ADCAs as compared to normal lung tissue. Expression of RASSF8 protein by transfected lung cancer cells led to inhibition of anchorage-independent growth in soft agar in A549 cells and reduction of clonogenic activity in NCI-H520 cells. These results raise the possibility protein encoded by RASSF8 is a novel tumor suppressor for lung cancer.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0950-9232
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
29
|
| pubmed:volume |
25
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
3934-8
|
| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:16462760-5' Untranslated Regions,
pubmed-meshheading:16462760-Adenocarcinoma,
pubmed-meshheading:16462760-Base Sequence,
pubmed-meshheading:16462760-Cell Adhesion,
pubmed-meshheading:16462760-Cell Division,
pubmed-meshheading:16462760-Cell Line, Tumor,
pubmed-meshheading:16462760-Cloning, Molecular,
pubmed-meshheading:16462760-DNA Primers,
pubmed-meshheading:16462760-Down-Regulation,
pubmed-meshheading:16462760-Genes, Tumor Suppressor,
pubmed-meshheading:16462760-Humans,
pubmed-meshheading:16462760-Lung Neoplasms,
pubmed-meshheading:16462760-Molecular Sequence Data,
pubmed-meshheading:16462760-RNA, Messenger,
pubmed-meshheading:16462760-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:16462760-Transfection,
pubmed-meshheading:16462760-Tumor Suppressor Proteins
|
| pubmed:year |
2006
|
| pubmed:articleTitle |
Identification of RASSF8 as a candidate lung tumor suppressor gene.
|
| pubmed:affiliation |
Department of Experimental Oncology and Laboratories, Istituto Nazionale Tumori, Milan, Italy.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|