16462744

Source:http://linkedlifedata.com/resource/pubmed/id/16462744

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0015677, umls-concept:C0162610, umls-concept:C1698986, umls-concept:C2587213
pubmed:issue	3
pubmed:dateCreated	2006-2-27
pubmed:abstractText	Tubby mice and individuals with Bardet-Biedl syndrome have defects in ciliated neuron function and obesity, suggesting an as-yet unknown metabolic signaling axis from ciliated neurons to fat storage tissues. Here we show coordinate regulation of Caenorhabditis elegans fat storage by orthologues of these genes acting in ciliated neurons and by a 3-ketoacyl-coA thiolase (encoded by kat-1) that acts in fat storage tissue. A genetic screen for markedly enhanced fat storage in tub-1 mutants led to the isolation only of kat-1 alleles, which impair fatty acid beta-oxidation. kat-1 acts in the intestine, the major C. elegans fat storage tissue, and is transcriptionally upregulated in animals with high fat storage. A genetic screen for synergistic increase in fat storage of a kat-1 mutant identified bbs-1. bbs-1 acts in 15 ciliated neurons that are poised to sense external and internal nutrient levels, supporting a model in which bbs-1 and tub-1 in ciliated neurons form part of an ancient, conserved neuroendocrine axis. This pathway also includes genes encoding intraflagellar transport proteins and cyclic nucleotide gated channels, demonstrating that C. elegans fat storage is under polygenic control.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9216904
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Acetyl-CoA C-Acyltransferase
pubmed:status	MEDLINE
pubmed:month	Mar
pubmed:issn	1061-4036
pubmed:author	pubmed-author:BassonMichaelM, pubmed-author:JohnsonCarl DCD, pubmed-author:MakHo YiHY, pubmed-author:NelsonLaura SLS, pubmed-author:RuvkunGaryG
pubmed:issnType	Print
pubmed:volume	38
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	363-8
pubmed:dateRevised	2006-11-15
pubmed:meshHeading	pubmed-meshheading:16462744-Acetyl-CoA C-Acyltransferase, pubmed-meshheading:16462744-Adipose Tissue, pubmed-meshheading:16462744-Animals, pubmed-meshheading:16462744-Caenorhabditis elegans, pubmed-meshheading:16462744-Cilia, pubmed-meshheading:16462744-Mutation, pubmed-meshheading:16462744-Neurons
pubmed:year	2006
pubmed:articleTitle	Polygenic control of Caenorhabditis elegans fat storage.
pubmed:affiliation	Department of Molecular Biology, Massachusetts General Hospital, Boston 02114, USA.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural