|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
2006-2-24
|
|
pubmed:abstractText |
Vascular endothelial growth factor C (VEGF-C) was first identified as a regulator of the vascular system, where it is required for the development of lymphatic vessels. Here we report actions of VEGF-C in the central nervous system. We detected the expression of the VEGF-C receptor VEGFR-3 in neural progenitor cells in Xenopus laevis and mouse embryos. In Xenopus tadpole VEGF-C knockdowns and in mice lacking Vegfc, the proliferation of neural progenitors expressing VEGFR-3 was severely reduced, in the absence of intracerebral blood vessel defects. In addition, Vegfc-deficient mouse embryos showed a selective loss of oligodendrocyte precursor cells (OPCs) in the embryonic optic nerve. In vitro, VEGF-C stimulated the proliferation of OPCs expressing VEGFR-3 and nestin-positive ventricular neural cells. VEGF-C thus has a new, evolutionary conserved function as a growth factor selectively required by neural progenitor cells expressing its receptor VEGFR-3.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
1097-6256
|
|
pubmed:author |
pubmed-author:AlitaloKariK,
pubmed-author:BarallobreMaria-JoséMJ,
pubmed-author:BréantChristianeC,
pubmed-author:CarmelietPeterP,
pubmed-author:ChatzopoulouElliE,
pubmed-author:EichmannAnneA,
pubmed-author:HaikoPaulaP,
pubmed-author:Homman-LudiyeJihaneJ,
pubmed-author:KarkkainenMarika JMJ,
pubmed-author:Le BrasBarbaraB,
pubmed-author:LiYuanY,
pubmed-author:MurielMarie-PauleMP,
pubmed-author:NyAnneliiA,
pubmed-author:TammelaTuomasT,
pubmed-author:ThomasJean-LéonJL,
pubmed-author:WynsSabineS,
pubmed-author:ZalcBernardB
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
9
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
340-8
|
|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
pubmed-meshheading:16462734-Animals,
pubmed-meshheading:16462734-Brain,
pubmed-meshheading:16462734-Cell Differentiation,
pubmed-meshheading:16462734-Cells, Cultured,
pubmed-meshheading:16462734-Evolution, Molecular,
pubmed-meshheading:16462734-Intermediate Filament Proteins,
pubmed-meshheading:16462734-Larva,
pubmed-meshheading:16462734-Lateral Ventricles,
pubmed-meshheading:16462734-Mice,
pubmed-meshheading:16462734-Mice, Knockout,
pubmed-meshheading:16462734-Mice, Transgenic,
pubmed-meshheading:16462734-Nerve Growth Factors,
pubmed-meshheading:16462734-Nerve Tissue Proteins,
pubmed-meshheading:16462734-Neurons,
pubmed-meshheading:16462734-Oligodendroglia,
pubmed-meshheading:16462734-Optic Nerve,
pubmed-meshheading:16462734-Rats,
pubmed-meshheading:16462734-Rats, Wistar,
pubmed-meshheading:16462734-Stem Cells,
pubmed-meshheading:16462734-Vascular Endothelial Growth Factor C,
pubmed-meshheading:16462734-Vascular Endothelial Growth Factor Receptor-3,
pubmed-meshheading:16462734-Xenopus laevis
|
|
pubmed:year |
2006
|
|
pubmed:articleTitle |
VEGF-C is a trophic factor for neural progenitors in the vertebrate embryonic brain.
|
|
pubmed:affiliation |
Institut National de la Santé et de la Recherche Médicale (INSERM), U711, Paris F-75013, France.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|
