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rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0001675,
umls-concept:C0026809,
umls-concept:C0027051,
umls-concept:C0033414,
umls-concept:C0600520,
umls-concept:C1151928,
umls-concept:C1333336,
umls-concept:C1514873,
umls-concept:C1515655,
umls-concept:C1546857,
umls-concept:C1556066,
umls-concept:C1619636
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|
pubmed:issue |
5
|
|
pubmed:dateCreated |
2006-2-7
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|
pubmed:abstractText |
Left ventricular (LV) remodeling after myocardial infarction is associated with hypertrophy of surviving myocytes and represents a major process that leads to heart failure. One of the intrinsic histone acetyltransferases, p300, serves as a coactivator of hypertrophy-responsive transcriptional factors such as a cardiac zinc finger protein GATA-4 and is involved in its hypertrophic stimulus-induced acetylation and DNA binding. However, the role of p300-histone acetyltransferase activity in LV remodeling after myocardial infarction in vivo is unknown.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Feb
|
|
pubmed:issn |
1524-4539
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|
pubmed:author |
|
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pubmed:issnType |
Electronic
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pubmed:day |
7
|
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pubmed:volume |
113
|
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pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
679-90
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:16461841-Animals,
pubmed-meshheading:16461841-Cell Cycle Proteins,
pubmed-meshheading:16461841-GATA4 Transcription Factor,
pubmed-meshheading:16461841-Heart Failure,
pubmed-meshheading:16461841-Histone Acetyltransferases,
pubmed-meshheading:16461841-Hypertrophy,
pubmed-meshheading:16461841-Mice,
pubmed-meshheading:16461841-Mice, Transgenic,
pubmed-meshheading:16461841-Myocardial Infarction,
pubmed-meshheading:16461841-Myocytes, Cardiac,
pubmed-meshheading:16461841-Signal Transduction,
pubmed-meshheading:16461841-Transcription Factors,
pubmed-meshheading:16461841-Ventricular Remodeling,
pubmed-meshheading:16461841-p300-CBP Transcription Factors
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|
pubmed:year |
2006
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|
pubmed:articleTitle |
Histone acetyltransferase activity of p300 is required for the promotion of left ventricular remodeling after myocardial infarction in adult mice in vivo.
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pubmed:affiliation |
Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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