Linked Life Data

16459422

Source:http://linkedlifedata.com/resource/pubmed/id/16459422

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2006-2-6
pubmed:abstractText
A trivalent inorganic arsenic, arsenite, has been causing chronic inflammation in humans through the consumption of contaminated well water. The total peripheral blood arsenic concentrations of chronic arsenic-exposed patients, who had inflammatory-like immune responses, are less than 1 microM, thus, nM concentrations may be very important regarding the chronic inflammatory effects by arsenite. However, there are few reports about the biological effects of low concentrations of arsenite in mammalian cells, especially in normal immune effector cells. In this study, we examined whether arsenite has any biological and/or toxicological effects on the differentiation of human peripheral blood monocytes into macrophages using the colony-stimulating factor (CSF) in vitro compared with that of other metallic compounds, and found that arsenite sensitively inhibited the CSF-induced in vitro maturation of monocytes into macrophages at nM levels, and it also induced small, nonadhesive and CD14-positive abnormal macrophage generation from monocytes with granulocyte-macrophage CSF (GM-CSF) at 50-500 nM without cell death. The addition of other metallic compounds, including chromium, selenium, mercury, cadmium, nickel, copper, zinc, cobalt, manganese and other human pentavalent arsenic metabolites, such as inorganic arsenate, monomethylarsonic acid and dimethylarsinic acid, could not induce the same abnormal cell generation from monocytes with CSFs at any concentration and any additional time schedules; they showed only simple cytolethality in monocytes and macrophages at any concentration and any additional time schedules; they showed only simple cytolethality in monocytes and macrophages at n-mM levels accompanied by cell death. This work may have implications in the arsenic-induced chronic inflammation in humans.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1567-5769
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
304-15
pubmed:meshHeading
pubmed-meshheading:16459422-Arsenites, pubmed-meshheading:16459422-Cell Differentiation, pubmed-meshheading:16459422-Cell Survival, pubmed-meshheading:16459422-Cytokines, pubmed-meshheading:16459422-Environmental Pollutants, pubmed-meshheading:16459422-Glutathione, pubmed-meshheading:16459422-Granulocyte-Macrophage Colony-Stimulating Factor, pubmed-meshheading:16459422-HL-60 Cells, pubmed-meshheading:16459422-Humans, pubmed-meshheading:16459422-Immunity, Cellular, pubmed-meshheading:16459422-Immunotoxins, pubmed-meshheading:16459422-Interleukin-12, pubmed-meshheading:16459422-Macrophages, pubmed-meshheading:16459422-Monocytes, pubmed-meshheading:16459422-Nitric Oxide, pubmed-meshheading:16459422-Phenotype, pubmed-meshheading:16459422-Reactive Oxygen Species, pubmed-meshheading:16459422-T-Lymphocytes
pubmed:year
2006
pubmed:articleTitle
Evaluation of immunotoxic and immunodisruptive effects of inorganic arsenite on human monocytes/macrophages.
pubmed:affiliation
Laboratory of Environmental Chemistry, School of Life Science, Tokyo University of Pharmacy and Life Science, Horinouchi 1432-1, Hachioji, Tokyo 192-0392, Japan. sakurai@ph.bunri-u.ac.jp
pubmed:publicationType
Journal Article, Corrected and Republished Article