rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
2
|
pubmed:dateCreated |
2006-2-6
|
pubmed:abstractText |
Asymmetric localization of PAR proteins is a hallmark of polarized cells, but the mechanisms that create PAR asymmetry are not well understood. In the C. elegans zygote, PAR asymmetry is initiated by a transient actomyosin contraction, which sweeps the PAR-3/PAR-6/PKC-3 complex toward the anterior pole of the egg. The RING finger protein PAR-2 accumulates in a complementary pattern in the posterior cortex. Here we present evidence that PAR-2 participates in a feedback loop to stabilize polarity. PAR-2 is a target of the PKC-3 kinase and is excluded from the anterior cortex by PKC-3-dependent phosphorylation. The RING domain of PAR-2 is required to overcome inhibition by PKC-3 and stabilize PAR-2 on the posterior cortex. Cortical PAR-2 in turn prevents PAR-3/PAR-6/PKC-3 from returning to the posterior, in a PAR-1- and PAR-5-dependent manner. Our findings suggest that reciprocal inhibitory interactions among PAR proteins stabilize polarity by reinforcing an initial asymmetry in PKC-3.
|
pubmed:grant |
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16459299-10830161,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16459299-10882103,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16459299-10934475,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16459299-10998601,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16459299-11238406,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16459299-11347904,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16459299-11784094,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16459299-11914720,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16459299-12588843,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16459299-12615916,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16459299-12629552,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16459299-13129846,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16459299-14675534,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16459299-14676191,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16459299-14755799,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16459299-14991002,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16459299-15027470,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16459299-15084291,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16459299-15186741,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16459299-15324659,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16459299-15324689,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16459299-15363415,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16459299-15530417,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16459299-15694314,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16459299-15895077,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16459299-3345562,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16459299-4366476,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16459299-7758115,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16459299-8016123,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16459299-8521491,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16459299-8531731,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16459299-8531737,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16459299-8898221,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16459299-8898226,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16459299-9716526,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16459299-9804418
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Feb
|
pubmed:issn |
1534-5807
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
10
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
199-208
|
pubmed:dateRevised |
2011-3-8
|
pubmed:meshHeading |
pubmed-meshheading:16459299-Amino Acid Sequence,
pubmed-meshheading:16459299-Animals,
pubmed-meshheading:16459299-Binding Sites,
pubmed-meshheading:16459299-Caenorhabditis elegans,
pubmed-meshheading:16459299-Caenorhabditis elegans Proteins,
pubmed-meshheading:16459299-Cell Polarity,
pubmed-meshheading:16459299-Down-Regulation,
pubmed-meshheading:16459299-Feedback,
pubmed-meshheading:16459299-Female,
pubmed-meshheading:16459299-Genes, Helminth,
pubmed-meshheading:16459299-Male,
pubmed-meshheading:16459299-Molecular Sequence Data,
pubmed-meshheading:16459299-Phosphorylation,
pubmed-meshheading:16459299-Protein Kinase C,
pubmed-meshheading:16459299-Protein Structure, Tertiary,
pubmed-meshheading:16459299-Sequence Homology, Amino Acid,
pubmed-meshheading:16459299-Zygote
|
pubmed:year |
2006
|
pubmed:articleTitle |
Stabilization of cell polarity by the C. elegans RING protein PAR-2.
|
pubmed:affiliation |
Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
|
pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
|