Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2006-2-6
pubmed:abstractText
Asymmetric localization of PAR proteins is a hallmark of polarized cells, but the mechanisms that create PAR asymmetry are not well understood. In the C. elegans zygote, PAR asymmetry is initiated by a transient actomyosin contraction, which sweeps the PAR-3/PAR-6/PKC-3 complex toward the anterior pole of the egg. The RING finger protein PAR-2 accumulates in a complementary pattern in the posterior cortex. Here we present evidence that PAR-2 participates in a feedback loop to stabilize polarity. PAR-2 is a target of the PKC-3 kinase and is excluded from the anterior cortex by PKC-3-dependent phosphorylation. The RING domain of PAR-2 is required to overcome inhibition by PKC-3 and stabilize PAR-2 on the posterior cortex. Cortical PAR-2 in turn prevents PAR-3/PAR-6/PKC-3 from returning to the posterior, in a PAR-1- and PAR-5-dependent manner. Our findings suggest that reciprocal inhibitory interactions among PAR proteins stabilize polarity by reinforcing an initial asymmetry in PKC-3.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/16459299-10830161, http://linkedlifedata.com/resource/pubmed/commentcorrection/16459299-10882103, http://linkedlifedata.com/resource/pubmed/commentcorrection/16459299-10934475, http://linkedlifedata.com/resource/pubmed/commentcorrection/16459299-10998601, http://linkedlifedata.com/resource/pubmed/commentcorrection/16459299-11238406, http://linkedlifedata.com/resource/pubmed/commentcorrection/16459299-11347904, http://linkedlifedata.com/resource/pubmed/commentcorrection/16459299-11784094, http://linkedlifedata.com/resource/pubmed/commentcorrection/16459299-11914720, http://linkedlifedata.com/resource/pubmed/commentcorrection/16459299-12588843, http://linkedlifedata.com/resource/pubmed/commentcorrection/16459299-12615916, http://linkedlifedata.com/resource/pubmed/commentcorrection/16459299-12629552, http://linkedlifedata.com/resource/pubmed/commentcorrection/16459299-13129846, http://linkedlifedata.com/resource/pubmed/commentcorrection/16459299-14675534, http://linkedlifedata.com/resource/pubmed/commentcorrection/16459299-14676191, http://linkedlifedata.com/resource/pubmed/commentcorrection/16459299-14755799, http://linkedlifedata.com/resource/pubmed/commentcorrection/16459299-14991002, http://linkedlifedata.com/resource/pubmed/commentcorrection/16459299-15027470, http://linkedlifedata.com/resource/pubmed/commentcorrection/16459299-15084291, http://linkedlifedata.com/resource/pubmed/commentcorrection/16459299-15186741, http://linkedlifedata.com/resource/pubmed/commentcorrection/16459299-15324659, http://linkedlifedata.com/resource/pubmed/commentcorrection/16459299-15324689, http://linkedlifedata.com/resource/pubmed/commentcorrection/16459299-15363415, http://linkedlifedata.com/resource/pubmed/commentcorrection/16459299-15530417, http://linkedlifedata.com/resource/pubmed/commentcorrection/16459299-15694314, http://linkedlifedata.com/resource/pubmed/commentcorrection/16459299-15895077, http://linkedlifedata.com/resource/pubmed/commentcorrection/16459299-3345562, http://linkedlifedata.com/resource/pubmed/commentcorrection/16459299-4366476, http://linkedlifedata.com/resource/pubmed/commentcorrection/16459299-7758115, http://linkedlifedata.com/resource/pubmed/commentcorrection/16459299-8016123, http://linkedlifedata.com/resource/pubmed/commentcorrection/16459299-8521491, http://linkedlifedata.com/resource/pubmed/commentcorrection/16459299-8531731, http://linkedlifedata.com/resource/pubmed/commentcorrection/16459299-8531737, http://linkedlifedata.com/resource/pubmed/commentcorrection/16459299-8898221, http://linkedlifedata.com/resource/pubmed/commentcorrection/16459299-8898226, http://linkedlifedata.com/resource/pubmed/commentcorrection/16459299-9716526, http://linkedlifedata.com/resource/pubmed/commentcorrection/16459299-9804418
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1534-5807
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
199-208
pubmed:dateRevised
2011-3-8
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Stabilization of cell polarity by the C. elegans RING protein PAR-2.
pubmed:affiliation
Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural