Source:http://linkedlifedata.com/resource/pubmed/id/16458462
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2006-5-29
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| pubmed:abstractText |
Both Moutan cortex of Paeonia suffruticosa Andrews (MC) and the root of Paeonia lactiflora Pall (PL) are important Traditional Chinese herbs used commonly to treat inflammatory and pyretic disorders. Paeonol, a common component of MC causes anti-platelet aggregation and scavenges free radicals. Therefore, the aim of the present study is to investigate the effects of Paeonol on cerebral infarct. A total of 60 male Sprague-Dawley (SD) rats were studied. An animal model of cerebral infarct was established by occluding both common carotid arteries and the right middle cerebral artery for 90 min, followed by a 24 h period of reperfusion. The percentage of cerebral infarction area to total brain area in each piece of brain tissue, and neuro-deficit score were measured. Superoxide anion was determined by the number of lucigenin-chemiluminescence (CL) counts. ED1 (mouse anti rat CD68) and interleukin-1beta (IL-1beta) immunostaining in the cerebral infarction region were also investigated for activation of microglia. The results indicated that Paeonol 15 and 20 mg/kg pretreatment and 20 mg posttreatment reduced the cerebral infarction area; Paeonol 15 and 20 mg/kg pretreatment reduced the neuro-deficit score. In addition, Paeonol 20 mg/kg pretreatment reduced the lucigenin-CL counts at 2 h period of reperfusion. The number of ED1 and IL-1beta immunoreactive cells also reduced in the cerebral infarction region; there were no significant changes in blood sugar levels. The results show that Paeonol reduced cerebral infarct and neuro-deficit in rat, suggesting Paeonol might play a similar role in reducing cerebral infarction in humans. Paeonol suppresses and scavenges superoxide anion, and inhibit microglia activation and IL-1beta in ischemia-reperfusion injured rats.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acetophenones,
http://linkedlifedata.com/resource/pubmed/chemical/Ectodysplasins,
http://linkedlifedata.com/resource/pubmed/chemical/Free Radical Scavengers,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1beta,
http://linkedlifedata.com/resource/pubmed/chemical/Superoxides,
http://linkedlifedata.com/resource/pubmed/chemical/paeonol
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jun
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| pubmed:issn |
0378-8741
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:day |
30
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| pubmed:volume |
106
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
208-15
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| pubmed:meshHeading |
pubmed-meshheading:16458462-Acetophenones,
pubmed-meshheading:16458462-Animals,
pubmed-meshheading:16458462-Brain,
pubmed-meshheading:16458462-Cerebral Infarction,
pubmed-meshheading:16458462-Disease Models, Animal,
pubmed-meshheading:16458462-Dose-Response Relationship, Drug,
pubmed-meshheading:16458462-Ectodysplasins,
pubmed-meshheading:16458462-Free Radical Scavengers,
pubmed-meshheading:16458462-Interleukin-1beta,
pubmed-meshheading:16458462-Male,
pubmed-meshheading:16458462-Microglia,
pubmed-meshheading:16458462-Motor Activity,
pubmed-meshheading:16458462-Paeonia,
pubmed-meshheading:16458462-Plant Roots,
pubmed-meshheading:16458462-Random Allocation,
pubmed-meshheading:16458462-Rats,
pubmed-meshheading:16458462-Rats, Sprague-Dawley,
pubmed-meshheading:16458462-Reperfusion Injury,
pubmed-meshheading:16458462-Superoxides
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| pubmed:year |
2006
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| pubmed:articleTitle |
Paeonol reduced cerebral infarction involving the superoxide anion and microglia activation in ischemia-reperfusion injured rats.
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| pubmed:affiliation |
Department of Chinese Medicine, China Medical University Hospital, Taichung City, Taiwan.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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