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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
2006-12-25
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pubmed:abstractText |
We evaluated the association between the XPD exon 10 Asp(312)Asn and exon 23 Lys(751)Gln polymorphisms and the risk of pancreatic cancer in a hospital-based study of 344 patients and 386 controls frequency matched by age, gender, and race. Stratified analyses showed ever smokers carrying the Asn(312)Asn genotype had a significantly reduced risk when compared with those carrying the (312)Asp allele (OR=0.46, 95% confidence interval 0.24-0.88) (P for interaction=0.03). The (312)Asp-(751)Gln was identified as the putative at risk haplotype. Our study shows that the XPD gene polymorphism could be a genetic risk modifier for smoking-related pancreatic cancer.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16458430-10064862,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16458430-10688865,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16458430-10924514,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16458430-11007478,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16458430-11027268,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16458430-11238179,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/16458430-11254454,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16458430-11285194,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/16458430-11872635,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/16458430-12844488,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16458430-14729591,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16458430-14734699,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16458430-15199548,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16458430-15598761,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16458430-15661806,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16458430-15776433,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/16458430-9485007
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0304-3835
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
8
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pubmed:volume |
245
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
61-8
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:16458430-Adenocarcinoma,
pubmed-meshheading:16458430-Aged,
pubmed-meshheading:16458430-Amino Acid Substitution,
pubmed-meshheading:16458430-Asparagine,
pubmed-meshheading:16458430-Aspartic Acid,
pubmed-meshheading:16458430-Carcinoma, Pancreatic Ductal,
pubmed-meshheading:16458430-Case-Control Studies,
pubmed-meshheading:16458430-Female,
pubmed-meshheading:16458430-Gene Frequency,
pubmed-meshheading:16458430-Genotype,
pubmed-meshheading:16458430-Glutamine,
pubmed-meshheading:16458430-Haplotypes,
pubmed-meshheading:16458430-Humans,
pubmed-meshheading:16458430-Linkage Disequilibrium,
pubmed-meshheading:16458430-Lysine,
pubmed-meshheading:16458430-Male,
pubmed-meshheading:16458430-Middle Aged,
pubmed-meshheading:16458430-Pancreatic Neoplasms,
pubmed-meshheading:16458430-Polymorphism, Single Nucleotide,
pubmed-meshheading:16458430-Risk Factors,
pubmed-meshheading:16458430-Smoking,
pubmed-meshheading:16458430-Xeroderma Pigmentosum Group D Protein
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pubmed:year |
2007
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pubmed:articleTitle |
The XPD Asp312Asn and Lys751Gln polymorphisms, corresponding haplotype, and pancreatic cancer risk.
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pubmed:affiliation |
Department of Gastrointestinal Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Unit 426, 1515 Holcombe Boulevard, Houston, TX 77030, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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