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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2006-4-17
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pubmed:abstractText |
Bacterial DNA and synthetic oligonucleotides containing unmethylated motifs have become the focus of many studies due to their ability to activate cells of the innate immune system through interaction with Toll-like receptor 9 (TLR9). This study was undertaken to investigate if and how CpG-oligonucleotides (CpGs) activate liver sinusoidal endothelial cells (LSECs), known to be the main site of clearance of DNA-oligonucleotides from the circulation.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0168-8278
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pubmed:author |
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|
pubmed:issnType |
Print
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pubmed:volume |
44
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
939-46
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16458386-Animals,
pubmed-meshheading:16458386-Cells, Cultured,
pubmed-meshheading:16458386-Endosomes,
pubmed-meshheading:16458386-Endothelial Cells,
pubmed-meshheading:16458386-Immunohistochemistry,
pubmed-meshheading:16458386-Interleukin-1,
pubmed-meshheading:16458386-Interleukin-6,
pubmed-meshheading:16458386-Iodine Radioisotopes,
pubmed-meshheading:16458386-Liver,
pubmed-meshheading:16458386-Lysosomes,
pubmed-meshheading:16458386-Male,
pubmed-meshheading:16458386-Mice,
pubmed-meshheading:16458386-Mice, Inbred BALB C,
pubmed-meshheading:16458386-Oligodeoxyribonucleotides,
pubmed-meshheading:16458386-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:16458386-Signal Transduction,
pubmed-meshheading:16458386-Toll-Like Receptor 9
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pubmed:year |
2006
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pubmed:articleTitle |
Toll-like receptor 9 (TLR9) is present in murine liver sinusoidal endothelial cells (LSECs) and mediates the effect of CpG-oligonucleotides.
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pubmed:affiliation |
Department of Experimental Pathology, Institute of Medical Biology, University of Tromsø, N-9037, Tromsø, Norway. montse@fagmed.uit.no
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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