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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2006-2-14
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pubmed:abstractText |
To understand differential time activation of nuclear factor kappaB (NF-kappaB) and the temporal features of the downstream pro-inflammatory cytokines' [tumour-necrosis-factor-alpha (TNF-alpha) and IP-10] mRNA levels in myeloid differentiation primary-response protein 88 (MyD88) knockouts (KOs), I developed a computational model of the TLR4 pathway. The result suggests that the late phase expression of NF-kappaB activity observed in MyD88 KOs is possibly due to a number of novel intermediates acting along the MyD88-independent pathway. I also simulate that the TNF-alpha levels will increase at a longer time in MyD88 KOs, not previously mentioned.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0014-5793
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
20
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pubmed:volume |
580
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1457-64
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16458306-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:16458306-Animals,
pubmed-meshheading:16458306-Animals, Genetically Modified,
pubmed-meshheading:16458306-Computer Simulation,
pubmed-meshheading:16458306-Kinetics,
pubmed-meshheading:16458306-Models, Biological,
pubmed-meshheading:16458306-Myeloid Differentiation Factor 88,
pubmed-meshheading:16458306-NF-kappa B,
pubmed-meshheading:16458306-Signal Transduction,
pubmed-meshheading:16458306-Toll-Like Receptor 4,
pubmed-meshheading:16458306-Tumor Necrosis Factor-alpha
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pubmed:year |
2006
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pubmed:articleTitle |
Discovering differential activation machinery of the Toll-like receptor 4 signaling pathways in MyD88 knockouts.
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pubmed:affiliation |
Cell Interaction Group, Bioinformatics Institute, 138671, Singapore. kumars@bii.a-star.edu.sg
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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