| pubmed-article:16458123 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16458123 | lifeskim:mentions | umls-concept:C0006644 | lld:lifeskim |
| pubmed-article:16458123 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:16458123 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:16458123 | lifeskim:mentions | umls-concept:C0207509 | lld:lifeskim |
| pubmed-article:16458123 | lifeskim:mentions | umls-concept:C1512409 | lld:lifeskim |
| pubmed-article:16458123 | lifeskim:mentions | umls-concept:C0439855 | lld:lifeskim |
| pubmed-article:16458123 | lifeskim:mentions | umls-concept:C0392747 | lld:lifeskim |
| pubmed-article:16458123 | lifeskim:mentions | umls-concept:C1552961 | lld:lifeskim |
| pubmed-article:16458123 | lifeskim:mentions | umls-concept:C1554963 | lld:lifeskim |
| pubmed-article:16458123 | lifeskim:mentions | umls-concept:C0045822 | lld:lifeskim |
| pubmed-article:16458123 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:16458123 | pubmed:dateCreated | 2006-2-6 | lld:pubmed |
| pubmed-article:16458123 | pubmed:abstractText | 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), one of the most abundant carcinogenic heterocyclic amines in cooked foods, is speculated to be a human liver carcinogen. To test the hypothesis that it is metabolically activated by CYP1A2, we here investigated the effects of caffeine as a CYP1A2 inducer on MeIQx induced rat hepatocarcinogenesis in a medium-term liver bioassay system. Unexpectedly, no modifying effects of caffeine on MeIQx-induced hepatocarcinogenesis were evident, although up-regulation of CYP1A2 and NAT2 were detected. Therefore, mRNAs extracted from GST-P positive foci and the surrounding liver tissue in each group were analyzed to explore mechanisms in detail. The results suggest that suppression of syndecan-2 (Sdc2) and induction of cell cycle arrest through a p21-dependent pathway might have counter-acted any promotion effects of up-regulation of CYP1A2. | lld:pubmed |
| pubmed-article:16458123 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16458123 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16458123 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16458123 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16458123 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16458123 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16458123 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16458123 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16458123 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16458123 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16458123 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16458123 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16458123 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16458123 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16458123 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16458123 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16458123 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16458123 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:16458123 | pubmed:issn | 0304-3835 | lld:pubmed |
| pubmed-article:16458123 | pubmed:author | pubmed-author:ShiraiTomoyuk... | lld:pubmed |
| pubmed-article:16458123 | pubmed:author | pubmed-author:AsamotoMakoto... | lld:pubmed |
| pubmed-article:16458123 | pubmed:author | pubmed-author:HokaiwadoNaom... | lld:pubmed |
| pubmed-article:16458123 | pubmed:author | pubmed-author:SuzukiShugoS | lld:pubmed |
| pubmed-article:16458123 | pubmed:author | pubmed-author:OgawaKumikoK | lld:pubmed |
| pubmed-article:16458123 | pubmed:author | pubmed-author:KuribayashiMa... | lld:pubmed |
| pubmed-article:16458123 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16458123 | pubmed:day | 8 | lld:pubmed |
| pubmed-article:16458123 | pubmed:volume | 232 | lld:pubmed |
| pubmed-article:16458123 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16458123 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16458123 | pubmed:pagination | 289-99 | lld:pubmed |
| pubmed-article:16458123 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:16458123 | pubmed:meshHeading | pubmed-meshheading:16458123... | lld:pubmed |
| pubmed-article:16458123 | pubmed:meshHeading | pubmed-meshheading:16458123... | lld:pubmed |
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| pubmed-article:16458123 | pubmed:meshHeading | pubmed-meshheading:16458123... | lld:pubmed |
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| pubmed-article:16458123 | pubmed:meshHeading | pubmed-meshheading:16458123... | lld:pubmed |
| pubmed-article:16458123 | pubmed:meshHeading | pubmed-meshheading:16458123... | lld:pubmed |
| pubmed-article:16458123 | pubmed:meshHeading | pubmed-meshheading:16458123... | lld:pubmed |
| pubmed-article:16458123 | pubmed:meshHeading | pubmed-meshheading:16458123... | lld:pubmed |
| pubmed-article:16458123 | pubmed:meshHeading | pubmed-meshheading:16458123... | lld:pubmed |
| pubmed-article:16458123 | pubmed:meshHeading | pubmed-meshheading:16458123... | lld:pubmed |
| pubmed-article:16458123 | pubmed:meshHeading | pubmed-meshheading:16458123... | lld:pubmed |
| pubmed-article:16458123 | pubmed:meshHeading | pubmed-meshheading:16458123... | lld:pubmed |
| pubmed-article:16458123 | pubmed:meshHeading | pubmed-meshheading:16458123... | lld:pubmed |
| pubmed-article:16458123 | pubmed:meshHeading | pubmed-meshheading:16458123... | lld:pubmed |
| pubmed-article:16458123 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16458123 | pubmed:articleTitle | Lack of modification of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) rat hepatocarcinogenesis by caffeine, a CYP1A2 inducer, points to complex counteracting influences. | lld:pubmed |
| pubmed-article:16458123 | pubmed:affiliation | Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan. kuribayashi@ono.co.jp | lld:pubmed |
| pubmed-article:16458123 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16458123 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:25615 | entrezgene:pubmed | pubmed-article:16458123 | lld:entrezgene |
