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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2006-2-6
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pubmed:abstractText |
2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), one of the most abundant carcinogenic heterocyclic amines in cooked foods, is speculated to be a human liver carcinogen. To test the hypothesis that it is metabolically activated by CYP1A2, we here investigated the effects of caffeine as a CYP1A2 inducer on MeIQx induced rat hepatocarcinogenesis in a medium-term liver bioassay system. Unexpectedly, no modifying effects of caffeine on MeIQx-induced hepatocarcinogenesis were evident, although up-regulation of CYP1A2 and NAT2 were detected. Therefore, mRNAs extracted from GST-P positive foci and the surrounding liver tissue in each group were analyzed to explore mechanisms in detail. The results suggest that suppression of syndecan-2 (Sdc2) and induction of cell cycle arrest through a p21-dependent pathway might have counter-acted any promotion effects of up-regulation of CYP1A2.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2-amino-3,8-dimethylimidazo(4,5-f)qu...,
http://linkedlifedata.com/resource/pubmed/chemical/Acetyltransferases,
http://linkedlifedata.com/resource/pubmed/chemical/Caffeine,
http://linkedlifedata.com/resource/pubmed/chemical/Carcinogens,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 CYP1A2,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochromes,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proteoglycans,
http://linkedlifedata.com/resource/pubmed/chemical/Quinoxalines,
http://linkedlifedata.com/resource/pubmed/chemical/SDC2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Sdc2 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Syndecan-2,
http://linkedlifedata.com/resource/pubmed/chemical/cytochrome P-448
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0304-3835
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
8
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pubmed:volume |
232
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
289-99
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:16458123-Acetyltransferases,
pubmed-meshheading:16458123-Animals,
pubmed-meshheading:16458123-Caffeine,
pubmed-meshheading:16458123-Carcinogens,
pubmed-meshheading:16458123-Cytochrome P-450 CYP1A2,
pubmed-meshheading:16458123-Cytochromes,
pubmed-meshheading:16458123-Enzyme Induction,
pubmed-meshheading:16458123-Liver Neoplasms, Experimental,
pubmed-meshheading:16458123-Male,
pubmed-meshheading:16458123-Membrane Glycoproteins,
pubmed-meshheading:16458123-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:16458123-Proteoglycans,
pubmed-meshheading:16458123-Quinoxalines,
pubmed-meshheading:16458123-Rats,
pubmed-meshheading:16458123-Rats, Inbred F344,
pubmed-meshheading:16458123-Syndecan-2
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pubmed:year |
2006
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pubmed:articleTitle |
Lack of modification of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) rat hepatocarcinogenesis by caffeine, a CYP1A2 inducer, points to complex counteracting influences.
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pubmed:affiliation |
Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan. kuribayashi@ono.co.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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