Source:http://linkedlifedata.com/resource/pubmed/id/16455621
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2006-3-9
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| pubmed:abstractText |
Matrix metalloproteinases (MMPs) may contribute to the development of endometriosis. The aim of this study was to assess the effects of the polymorphisms in the promoters of MMP-7 (181A/G) and MMP-9 (1562C/T) on the risk of occurrence of endometriosis and adenomyosis. We genotyped 219 patients (143 women with endometriosis, 76 women with adenomyosis) and 160 control women in North China. There was a significant difference in frequency of the MMP-7 genotype between endometriosis and controls (P = 0.01) and also between adenomyosis and controls (P = 0.01). The frequency of the G allele in two groups of patients (7.3 and 7.9%) was significantly higher than in the controls (2.8%) (P = 0.01 and 0.01, respectively). Compared to the A/A genotype, the genotype with the -181G allele showed a significantly increased susceptibility to both diseases, with adjusted odds ratio of 2.62 [95% confidence interval (CI) = 1.17-5.87] for endometriosis and 3.14 (95% CI = 1.26-7.81) for adenomyosis. However, the overall genotype and allelotype distribution of the MMP-9 in the two case groups were not different from that of controls. We conclude that MMP-7-181A/G polymorphism has a potential to be a susceptibility factor for endometriosis and adenomyosis while MMP-9-1562C/T polymorphism may not provide a useful marker to predict susceptibility to endometriosis and adenomyosis, at least in women from North China.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jan
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| pubmed:issn |
1360-9947
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
12
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
35-9
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| pubmed:meshHeading |
pubmed-meshheading:16455621-Adult,
pubmed-meshheading:16455621-China,
pubmed-meshheading:16455621-Endometriosis,
pubmed-meshheading:16455621-Female,
pubmed-meshheading:16455621-Genetic Predisposition to Disease,
pubmed-meshheading:16455621-Humans,
pubmed-meshheading:16455621-Matrix Metalloproteinase 7,
pubmed-meshheading:16455621-Matrix Metalloproteinase 9,
pubmed-meshheading:16455621-Middle Aged,
pubmed-meshheading:16455621-Polymorphism, Single Nucleotide,
pubmed-meshheading:16455621-Promoter Regions, Genetic
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| pubmed:year |
2006
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| pubmed:articleTitle |
Polymorphisms in the promoter regions of the matrix metalloproteinases-7, -9 and the risk of endometriosis and adenomyosis in China.
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| pubmed:affiliation |
Department of Obstetrics and Gynaecology, Hebei Medical University, Fourth Hospital, Shijiazhuang, China.
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| pubmed:publicationType |
Journal Article
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