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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2006-2-3
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pubmed:abstractText |
The mechanism by which pancreatitis causes pain is unknown. The neuropeptide calcitonin gene-related peptide (CGRP) is released after sensory nerve activation and promotes nociceptive signaling in models of visceral pain. We hypothesized that acute pancreatitis leads to the activation of pancreatic sensory neurons that release CGRP in the dorsal horn of the spinal cord. This signal is ultimately transmitted to the brain, and pain is sensed.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0039-6060
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
139
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
197-201
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:16455328-Acute Disease,
pubmed-meshheading:16455328-Animals,
pubmed-meshheading:16455328-Arginine,
pubmed-meshheading:16455328-Calcitonin Gene-Related Peptide,
pubmed-meshheading:16455328-Disease Models, Animal,
pubmed-meshheading:16455328-Male,
pubmed-meshheading:16455328-Necrosis,
pubmed-meshheading:16455328-Pain,
pubmed-meshheading:16455328-Pancreatitis,
pubmed-meshheading:16455328-Posterior Horn Cells,
pubmed-meshheading:16455328-Rats,
pubmed-meshheading:16455328-Rats, Sprague-Dawley
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pubmed:year |
2006
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pubmed:articleTitle |
Calcitonin gene-related peptide partially mediates nociception in acute experimental pancreatitis.
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pubmed:affiliation |
Department of Surgery, University of California, San Francisco, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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