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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1991-7-3
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pubmed:databankReference |
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pubmed:abstractText |
The Saccharomyces cerevisiae SRK1 gene, when expressed on a low-copy shuttle vector, partially suppresses the phenotype associated with elevated levels of cyclic AMP-dependent protein kinase activity and suppresses the temperature-sensitive cell cycle arrest of the ins1 mutant. SRK1 is located on chromosome IV, 3 centimorgans from gcn2. A mutant carrying a deletion mutation in srk1 is viable. SRK1 encodes a 140-kDa protein with homology to the dis3+ protein from Schizosaccharomyces pombe. The ability of SRK1 to alleviate partially the defects caused by high levels of cyclic AMP-dependent protein kinase and the similarity of its encoded protein to dis3+ suggest that SRK1 may have a role in protein phosphatase function.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1645449-1848673,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1645449-2166691,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1645449-2170029,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1645449-2176150,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1645449-2199315,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1645449-2537149,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1645449-2538815,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1645449-2541922,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1645449-2544298,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1645449-2549856,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1645449-2823100,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1645449-2827010,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1645449-2845400,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1645449-2848250,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1645449-3013722,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1645449-3037314,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1645449-3291115,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1645449-3409871,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1645449-357984,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1645449-3881393,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1645449-3889913,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1645449-6336730
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0270-7306
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
11
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pubmed:geneSymbol |
bcy1,
dis3+,
ins1,
srk1
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3369-73
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:1645449-Amino Acid Sequence,
pubmed-meshheading:1645449-Base Sequence,
pubmed-meshheading:1645449-Cloning, Molecular,
pubmed-meshheading:1645449-DNA, Fungal,
pubmed-meshheading:1645449-Genes, Fungal,
pubmed-meshheading:1645449-Genes, Suppressor,
pubmed-meshheading:1645449-Genetic Vectors,
pubmed-meshheading:1645449-Molecular Sequence Data,
pubmed-meshheading:1645449-Open Reading Frames,
pubmed-meshheading:1645449-Phosphoprotein Phosphatases,
pubmed-meshheading:1645449-Plasmids,
pubmed-meshheading:1645449-Restriction Mapping,
pubmed-meshheading:1645449-Saccharomyces cerevisiae,
pubmed-meshheading:1645449-Sequence Homology, Nucleic Acid
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pubmed:year |
1991
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pubmed:articleTitle |
The Saccharomyces cerevisiae SRK1 gene, a suppressor of bcy1 and ins1, may be involved in protein phosphatase function.
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pubmed:affiliation |
Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia 19104-4283.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
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