Source:http://linkedlifedata.com/resource/pubmed/id/16453697
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
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| pubmed:dateCreated |
2010-6-28
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| pubmed:abstractText |
Hydra forced to regenerate a head releases head activator and head inhibitor during the first hours after cutting to induce head-specific growth and differentiation processes. Analysis of the size distribution demonstrated that the head-activator peptide is co-released with (a) large molecular weight carrier molecule(s) to which it is non-covalently bound. The carrier-bound head activator is fully active on Hydra indicating that a carrier does not hinder the interaction with receptors. In contrast to this the head inhibitor is released in its naked, low molecular mass form. The association or non-association with a carrier molecule results in marked differences in biological properties. The head activator has a short range of action, but a long half-life, the head inhibitor has a global range of action, but a short half-life. These results provide a plausible explanation why two antagonistically acting substances, although they are released from the same site and simultaneously nevertheless can give rise to a well-defined temporal and spatial pattern of differentiation as occurs, for example, during head regeneration in Hydra.
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| pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16453697-14289615,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16453697-16593123,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16453697-2410027,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16453697-2577954,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16453697-3907660,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16453697-4663624,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16453697-4722157,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16453697-6086405,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16453697-6697993,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16453697-6825954,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16453697-6825956,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16453697-7183858
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:status |
PubMed-not-MEDLINE
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| pubmed:month |
Aug
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| pubmed:issn |
0261-4189
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
5
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1821-4
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| pubmed:dateRevised |
2010-9-20
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| pubmed:year |
1986
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| pubmed:articleTitle |
The head activator is released from regenerating Hydra bound to a carrier molecule.
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| pubmed:affiliation |
ZMBH, Zentrum für Molekulare Biologie, Im Neuenheimer Feld 282, 6900 Heidelberg, FRG.
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| pubmed:publicationType |
Journal Article
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