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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2006-2-2
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pubmed:abstractText |
In 1716 individuals--801 human immunodeficiency virus (HIV)-1-seropositive individuals, 217 high-risk HIV-1-seronegative individuals, and 698 general HIV-1-seronegative individuals--from a Seattle cohort and a Multicenter AIDS Cohort Study cohort, the association between HIV-1 susceptibility and repeat-region polymorphisms in the gene for the dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin-related molecule (DC-SIGNR) was investigated; 16 genotypes were found in the DC-SIGNR repeat region. The DC-SIGNR homozygous 7/7 repeat was found to be associated with an increased risk of HIV-1 infection (17.5% in high-risk HIV-1-seronegative individuals vs. 28.5% in HIV-1-seropositive individuals; P=.0015), whereas the DC-SIGNR heterozygous 7/5 repeat tended to be correlated with resistance to HIV-1 infection (35.5% in high-risk HIV-1-seronegative individuals vs. 27.6% in HIV-1-seropositive individuals; P=.0291). These findings suggest that DC-SIGNR polymorphisms may influence susceptibility to HIV-1.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0022-1899
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pubmed:author |
pubmed-author:CarringtonMaryM,
pubmed-author:CelumConnieC,
pubmed-author:CoreyLawrenceL,
pubmed-author:DetelsRogerR,
pubmed-author:GreeneBenjaminB,
pubmed-author:HUMEAA,
pubmed-author:HladikFlorianF,
pubmed-author:HolteSarahS,
pubmed-author:KoelleDavid MDM,
pubmed-author:KurosawaKyokoK,
pubmed-author:LiuHuanliangH,
pubmed-author:McElrathM JulianaMJ,
pubmed-author:RinaldoCharles RCR,
pubmed-author:WaldAnnaA,
pubmed-author:WangChunhuiC,
pubmed-author:ZhuTuofuT
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
193
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
698-702
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:16453266-Cell Adhesion Molecules,
pubmed-meshheading:16453266-Cohort Studies,
pubmed-meshheading:16453266-Genetic Predisposition to Disease,
pubmed-meshheading:16453266-Genotype,
pubmed-meshheading:16453266-HIV Infections,
pubmed-meshheading:16453266-HIV Seropositivity,
pubmed-meshheading:16453266-HIV-1,
pubmed-meshheading:16453266-Humans,
pubmed-meshheading:16453266-Lectins, C-Type,
pubmed-meshheading:16453266-Polymorphism, Genetic,
pubmed-meshheading:16453266-Receptors, Cell Surface,
pubmed-meshheading:16453266-Repetitive Sequences, Nucleic Acid
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pubmed:year |
2006
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pubmed:articleTitle |
Repeat-region polymorphisms in the gene for the dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin-related molecule: effects on HIV-1 susceptibility.
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pubmed:affiliation |
Department of Laboratory Medicine, University of Washington School of Medicine, Seattle, Washington 98195-8070, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Multicenter Study,
Research Support, N.I.H., Extramural
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