Linked Life Data

16452670

Source:http://linkedlifedata.com/resource/pubmed/id/16452670

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2006-2-2
pubmed:abstractText
Endocannabinoid signaling couples activity-dependent rises in postsynaptic Ca2+ levels to decreased presynaptic GABA release. Here, we present evidence from paired recording experiments that cannabinoid-mediated inhibition of GABA release depends on the firing rates of the presynaptic interneurons. Low-frequency action potentials in post hoc identified cholecystokinin-positive CA1 basket cells elicited IPSCs in the postsynaptic pyramidal cells that, as expected, were fully abolished by the exogenous application of the cannabinoid receptor agonist WIN55,212-2 [R-(+)-(2,3-dihydro-5-methyl-3-[(4-morpholinyl)methyl]pyrol[1,2,3-de]-1,4-benzoxazin-6-yl)(1-naphthalenyl) methanone monomethanesulfonate] at 5 microM. However, the presynaptic basket cells recovered from the cannabinoid agonist-induced inhibition of GABA release when the presynaptic firing rate was increased to > or =20 Hz. Pharmacological experiments showed that the recovered transmission was exclusively dependent on presynaptic N-type Ca2+ channels. Furthermore, the increased presynaptic firing could also overcome even complete depolarization-induced suppression of inhibition, indicating that the magnitude of DSI markedly depends on the activity levels of basket cells. These results reveal a new locus of activity-dependent modulation for endocannabinoid signaling and suggest that endocannabinoid-mediated inhibition of GABA release may differ in distinct behavioral states.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1529-2401
pubmed:author
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
26
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1465-9
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:16452670-Action Potentials, pubmed-meshheading:16452670-Animals, pubmed-meshheading:16452670-Benzoxazines, pubmed-meshheading:16452670-Calcium Channels, N-Type, pubmed-meshheading:16452670-Cannabinoids, pubmed-meshheading:16452670-Cholecystokinin, pubmed-meshheading:16452670-Evoked Potentials, pubmed-meshheading:16452670-Hippocampus, pubmed-meshheading:16452670-Interneurons, pubmed-meshheading:16452670-Morpholines, pubmed-meshheading:16452670-Naphthalenes, pubmed-meshheading:16452670-Neural Inhibition, pubmed-meshheading:16452670-Neuronal Plasticity, pubmed-meshheading:16452670-Patch-Clamp Techniques, pubmed-meshheading:16452670-Presynaptic Terminals, pubmed-meshheading:16452670-Pyramidal Cells, pubmed-meshheading:16452670-Rats, pubmed-meshheading:16452670-Rats, Sprague-Dawley, pubmed-meshheading:16452670-Receptor, Cannabinoid, CB1, pubmed-meshheading:16452670-Synaptic Transmission, pubmed-meshheading:16452670-gamma-Aminobutyric Acid
pubmed:year
2006
pubmed:articleTitle
Presynaptic, activity-dependent modulation of cannabinoid type 1 receptor-mediated inhibition of GABA release.
pubmed:affiliation
Department of Anatomy and Neurobiology, University of California, Irvine, California 92697-1280, USA. cfoldy@uci.edu
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural