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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2006-2-2
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pubmed:abstractText |
CHEK2*1100delC is a frame-shifting germ-line mutation which abolishes the function of cell-cycle-checkpoint kinase 2 (chk2) and hence impairs the cells' response to DNA damage. This variant occurs in 1% of the general Western population but has been reported to be more common among patients with breast and prostate cancer. The aim of this study was to investigate the significance of CHEK2*1100delC as a possible high-risk gene for hereditary prostate cancer in the population of southern Sweden.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0036-5599
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
40
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
23-5
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pubmed:dateRevised |
2011-11-2
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pubmed:meshHeading |
pubmed-meshheading:16452051-Aged,
pubmed-meshheading:16452051-Case-Control Studies,
pubmed-meshheading:16452051-DNA, Neoplasm,
pubmed-meshheading:16452051-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:16452051-Genetic Predisposition to Disease,
pubmed-meshheading:16452051-Germ-Line Mutation,
pubmed-meshheading:16452051-Humans,
pubmed-meshheading:16452051-Incidence,
pubmed-meshheading:16452051-Male,
pubmed-meshheading:16452051-Middle Aged,
pubmed-meshheading:16452051-Pedigree,
pubmed-meshheading:16452051-Polymerase Chain Reaction,
pubmed-meshheading:16452051-Prognosis,
pubmed-meshheading:16452051-Prostatic Neoplasms,
pubmed-meshheading:16452051-Protein-Serine-Threonine Kinases,
pubmed-meshheading:16452051-Risk Assessment,
pubmed-meshheading:16452051-Sweden
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pubmed:year |
2006
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pubmed:articleTitle |
CHEK2*1100delC is not an important high-risk gene in families with hereditary prostate cancer in southern Sweden.
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pubmed:affiliation |
Unit of Urology, Helsingborg Hospital, Helsingborg, Sweden. magnus.wagenius@helsingborgslasarett.se
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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