Linked Life Data

16451713

Source:http://linkedlifedata.com/resource/pubmed/id/16451713

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2010-1-19
pubmed:abstractText
We explored the power and consistency to detect linkage and association with meta-analysis and pooled data analysis using Genetic Analysis Workshop 14 simulated data. The first 10 replicates from Aipotu population were used. Significant linkage and association was found at all 4 regions containing the major loci for Kofendrerd Personality Disorder (KPD) using both combined analyses although no significant linkage and association was found at all these regions in a single replicate. The linkage results from both analyses are consistent in terms of the significance level of linkage test and the estimate of locus location. After correction for multiple-testing, significant associations were detected for the same 8 single-nucleotide polymorphisms (SNP) in both analyses. There were another 2 SNPs for which significant associations with KPD were found only by pooled data analysis. Our study showed that, under homogeneous condition, the results from meta-analysis and pooled data analysis are similar in both linkage and association studies and the loss of power is limited using meta-analysis. Thus, meta-analysis can provide an overall evaluation of linkage and association when the original raw data is not available for combining.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/16451713-10738538, http://linkedlifedata.com/resource/pubmed/commentcorrection/16451713-10782012, http://linkedlifedata.com/resource/pubmed/commentcorrection/16451713-10802644, http://linkedlifedata.com/resource/pubmed/commentcorrection/16451713-11058432, http://linkedlifedata.com/resource/pubmed/commentcorrection/16451713-11967554, http://linkedlifedata.com/resource/pubmed/commentcorrection/16451713-14997420, http://linkedlifedata.com/resource/pubmed/commentcorrection/16451713-4157472, http://linkedlifedata.com/resource/pubmed/commentcorrection/16451713-7581446, http://linkedlifedata.com/resource/pubmed/commentcorrection/16451713-8447318, http://linkedlifedata.com/resource/pubmed/commentcorrection/16451713-8666377, http://linkedlifedata.com/resource/pubmed/commentcorrection/16451713-8894640, http://linkedlifedata.com/resource/pubmed/commentcorrection/16451713-9345087, http://linkedlifedata.com/resource/pubmed/commentcorrection/16451713-9811422
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
1471-2156
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
6 Suppl 1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S97
pubmed:dateRevised
2010-9-20
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Identifying genetic variation affecting a complex trait in simulated data: a comparison of meta-analysis with pooled data analysis.
pubmed:affiliation
Department of Preventive Medicine and Epidemiology, Loyola University Chicago Medical Center, Maywood, IL, USA. xwu@apache.medctr.luhs.org
pubmed:publicationType
Journal Article, Comparative Study, Research Support, N.I.H., Extramural