Source:http://linkedlifedata.com/resource/pubmed/id/16450315
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2006-2-1
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| pubmed:abstractText |
The occurrence of antinuclear antibody (ANA), rheumatoid factor (RF), antibodies to double-stranded DNA (anti-dsDNA) and to single-stranded DNA (anti-ssDNA) was investigated in 51 patients with autoimmune thyroid diseases (AITD), and in 25 matched control subjects. In comparison with controls, the prevalence of anti-dsDNA was 74.5% in AITD patients (p=0.0001), 82.0% in 39 hyperthyroid Graves' disease (GD) (p=0.0001), and 50.0% in 12 euthyroid Hashimoto's thyroiditis (HT) patients (p=0.0001). The prevalence of anti-ssDNA was 90.1% in AITD (94.8% in GD and 75% in HT; p=0.001). The concentration of both anti-dsDNA and anti-ssDNA were higher (p=0.002) in AITD, in GD (p=0.001), and in HT (p=0.01) patients than in controls. Two patients with AITD were identified as positive for ANA. RF was detected in 4 AITD patients. Positive correlation was noted between anti-dsDNA with T4 (p=0.001), T3 (p=0.002), thyroid peroxidase antibody (anti-TPO) (p=0.0001), and TSH (p=0.001) values but not with thyroglobulin antibody (anti-Tg). Serum anti-ssDNA values were also correlated with T3 (p=0.0001), TSH (p=0.003), and anti-TPO (p=0.0001). However, by using a multiple regression analysis only anti-TPO remained associated with anti-dsDNA and both anti-Tg and anti-TPO with anti-ssDNA values. The predisposition to develop systemic autoimmune disorders is not influenced by thyroid hormones. The elevated prevalence of serum anti-dsDNA and anti-ssDNA in AITD patients points out that we must be aware of the risk for predisposition for the development of other systemic autoimmune diseases.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jan
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| pubmed:issn |
0947-7349
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
114
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
35-8
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| pubmed:meshHeading |
pubmed-meshheading:16450315-Adult,
pubmed-meshheading:16450315-Antibodies,
pubmed-meshheading:16450315-Antibodies, Antinuclear,
pubmed-meshheading:16450315-DNA,
pubmed-meshheading:16450315-DNA, Single-Stranded,
pubmed-meshheading:16450315-Female,
pubmed-meshheading:16450315-Graves Disease,
pubmed-meshheading:16450315-Hashimoto Disease,
pubmed-meshheading:16450315-Humans,
pubmed-meshheading:16450315-Male,
pubmed-meshheading:16450315-Reference Values,
pubmed-meshheading:16450315-Thyroid Function Tests
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| pubmed:year |
2006
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| pubmed:articleTitle |
Association of circulating antibodies against double-stranded and single-stranded DNA with thyroid autoantibodies in Graves' disease and Hashimoto's thyroiditis patients.
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| pubmed:affiliation |
Department of Endocrinology & Clinical Laboratory, Hospital do Servidor Público Estadual, IAMSPE, São Paulo, Brazil.
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| pubmed:publicationType |
Journal Article
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