Linked Life Data

16448544

Source:http://linkedlifedata.com/resource/pubmed/id/16448544

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2006-2-1
pubmed:abstractText
Transcriptional regulation of T-cell development involves successive interactions between complexes of transcriptional regulators and their binding sites within the regulatory regions of each gene. The regulatory modules that control expression of T-lineage genes frequently include binding sites for a core set of regulators that set the T-cell-specific background for signal-dependent control, including GATA-3, Notch/CSL, c-myb, TCF-1, Ikaros, HEB/E2A, Ets, and Runx factors. Additional regulators in early thymocytes include PU.1, Id-2, SCL, Spi-B, Erg, Gfi-1, and Gli. Many of these factors are involved in simultaneous regulation of non-T-lineage genes, T-lineage genes, and genes involved in cell cycle control, apoptosis, or survival. Potential and known interactions between early thymic transcription factors such as GATA-3, SCL, PU.1, Erg, and Spi-B are explored. Regulatory modules involved in the expression of several critical T-lineage genes are described, and models are presented for shifting occupancy of the DNA-binding sites in the regulatory modules of pre-Talpha, T-cell receptor beta (TCRbeta), recombinase activating genes 1 and 2 (Rag-1/2), and CD4 during T-cell development. Finally, evidence is presented that c-kit, Erg, Hes-1, and HEBAlt are expressed differently in Rag-2(-/-) thymocytes versus normal early thymocytes, which provide insight into potential regulatory interactions that occur during normal T-cell development.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0105-2896
pubmed:author
pubmed:issnType
Print
pubmed:volume
209
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
191-211
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:16448544-Animals, pubmed-meshheading:16448544-Gene Expression Regulation, Developmental, pubmed-meshheading:16448544-Gene Rearrangement, beta-Chain T-Cell Antigen Receptor, pubmed-meshheading:16448544-Gene Silencing, pubmed-meshheading:16448544-Hematopoietic Stem Cells, pubmed-meshheading:16448544-Humans, pubmed-meshheading:16448544-Interleukin-2, pubmed-meshheading:16448544-Lymphopoiesis, pubmed-meshheading:16448544-Mice, pubmed-meshheading:16448544-Proto-Oncogene Proteins, pubmed-meshheading:16448544-Receptors, Antigen, T-Cell, alpha-beta, pubmed-meshheading:16448544-T-Lymphocytes, pubmed-meshheading:16448544-Thymus Gland, pubmed-meshheading:16448544-Trans-Activators, pubmed-meshheading:16448544-Transcription, Genetic, pubmed-meshheading:16448544-Transcription Factors
pubmed:year
2006
pubmed:articleTitle
At the crossroads: diverse roles of early thymocyte transcriptional regulators.
pubmed:affiliation
Sunnybrook and Women's College Health Sciences Center, Division of Molecular and Cell Biology, University of Toronto, Department of Immunology, Toronto, ON, Canada. manderso@swri.ca
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't