Linked Life Data

1644661

Source:http://linkedlifedata.com/resource/pubmed/id/1644661

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1992-9-10
pubmed:abstractText
The present study reports the modulatory influences of combined oral contraceptive formulations, Ovral (0.05 mg ethinylestradiol plus 0.5 mg norgestrel per pill) and Noracycline (0.05 mg ethinylestradiol plus 0.1 mg lynestrenol per pill), on methylcholanthrene (MCA)-induced carcinogenesis in the uterine cervix of Swiss albino mouse. Placement of cotton thread impregnated with beeswax containing approximately 300 micrograms of MCA yielded cervical tumors in 0.0%, 8.6% and 26% animals, respectively, in 30, 60 and 90 days. Concomitant treatments with doses D1 (1/2000th of a pill), D2 (1/200th of a pill) and D3 (1/20th of a pill) of Ovral yielded cervical tumors in 0.0%, 0.0% and 4.5% mice at 30 days, 0.0%, 6.2% and 10% mice at 60 days and in 3.3% (P less than 0.05), 3.4% (P less than 0.05) and 47% mice at 90 days, respectively. Likewise, concomitant treatments with doses D1 (1/2000th of a pill), D2 (1/200th of a pill) and D3 (1/20th of a pill) of Noracycline yielded cervical tumors in 0.0%, 0.0%, 16.6% mice at 30 days, 4%, 3.7% and 54% (P less than 0.05) mice at 60 days and 3.2% (P less than 0.05), 20% and 63% (P less than 0.05) of mice at 90 days, respectively. Both Ovral and Noracycline displayed biphasic action on MCA-induced cervical carcinogenesis in mice. At lower dose levels (D1 and D2), they were inhibitory while at the higher dose level (D3) they were augmentatory in their actions. Both pills also significantly enhanced the incidence of cervical hyperplasia.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0910-5050
pubmed:author
pubmed:issnType
Print
pubmed:volume
83
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
576-83
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:1644661-Animals, pubmed-meshheading:1644661-Body Weight, pubmed-meshheading:1644661-Carcinoma, Squamous Cell, pubmed-meshheading:1644661-Contraceptives, Oral, Combined, pubmed-meshheading:1644661-Contraceptives, Oral, Synthetic, pubmed-meshheading:1644661-Dose-Response Relationship, Drug, pubmed-meshheading:1644661-Ethinyl Estradiol, pubmed-meshheading:1644661-Ethinyl Estradiol-Norgestrel Combination, pubmed-meshheading:1644661-Female, pubmed-meshheading:1644661-Lynestrenol, pubmed-meshheading:1644661-Mestranol, pubmed-meshheading:1644661-Methylcholanthrene, pubmed-meshheading:1644661-Mice, pubmed-meshheading:1644661-Norgestrel, pubmed-meshheading:1644661-Precancerous Conditions, pubmed-meshheading:1644661-Uterine Cervical Diseases, pubmed-meshheading:1644661-Uterine Cervical Neoplasms
pubmed:year
1992
pubmed:articleTitle
Modulatory influence of oral contraceptive pills Ovral and Noracycline on 3-methylcholanthrene-induced carcinogenesis in the uterine cervix of mouse.
pubmed:affiliation
Cancer Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't