Linked Life Data

16444188

Source:http://linkedlifedata.com/resource/pubmed/id/16444188

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2006-1-30
pubmed:abstractText
Glucose is the main cerebral fuel throughout life. Inadequate cerebral glucose supply, due to recurrent episodes of severe hypoglycemia during the neonatal period or infancy, when the brain is still developing, lead to serious long-term neurological impairments, ranging from mild neurocognitive dysfunction to severe mental retardation, epilepsy, microcephaly or even hemiparesis or aphasia. Moreover, in the most common form of severe recurrent hypoglycemia of infancy due to hyperinsulinism, not only abnormalities in neurocognitive function, but also the later development of diabetes mellitus are observed. Furthermore, recurrent hypoglycemia, supervening as a side-effect of intensified insulin treatment in young diabetic children, may also induce mild neurocognitive dysfunction and, specifically, memory deficits that predispose these children to new hypoglycemic episodes and hypoglycemia unawareness. In conclusion, prompt and meticulous management of hypoglycemia and its prevention during the neonatal period, infancy and childhood constitute the main goal of physicians taking care of these patients in order to ascertain a long-standing quality of life devoid of long-term sequelae.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1565-4753
pubmed:author
pubmed:issnType
Print
pubmed:volume
1 Suppl 3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
530-6
pubmed:dateRevised
2008-4-9
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Hypoglycemia in childhood: long-term effects.
pubmed:affiliation
Unit of Endocrinology, Diabetes and Metabolism, 1st Department of Pediatrics, University of Athens, School of Medicine, Agia Sophia Children's Hospital, Thivon and Livadias, Goudi, Athens, Greece. ganten@hol.gr
pubmed:publicationType
Journal Article, Review