16443450

Source:http://linkedlifedata.com/resource/pubmed/id/16443450

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0023317, umls-concept:C0036667, umls-concept:C0201699, umls-concept:C0205195, umls-concept:C0205288, umls-concept:C0312418, umls-concept:C0600596, umls-concept:C1511790, umls-concept:C1627358, umls-concept:C1708533, umls-concept:C2349975, umls-concept:C2698172
pubmed:issue	1-2
pubmed:dateCreated	2006-1-30
pubmed:abstractText	This paper reports a thermal lens microscope (TLM) detection coupled with capillary electrophoresis (CE) by using an interface chip (IFChip) to achieve highly sensitive detection with high reproducibility. Fused silica capillaries with an inner diameter of 50 microm were directly connected to a microchannel on the IFChip. In comparison with an on-capillary detection method in CE-TLM, ca. 10-fold improvements in the reproducibility for peak height were obtained by using IFChips. The detection limit of an azo dye was estimated to be 3.6 x 10(-7)M (100 ppb), which was above 100-times lower than that of conventional absorbance detection. Toward further improvement of the detectability for nonfluorescent compounds, on-line sample preconcentration by sweeping was applied to the CE-TLM using the IFChip. Due to the sweeping effect, 3900000-fold increase in the sensitivity was successfully achieved.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9318488
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	Feb
pubmed:issn	0021-9673
pubmed:author	pubmed-author:AkimotoYoshihiroY, pubmed-author:HattoriAkihikoA, pubmed-author:KitagawaFumihikoF, pubmed-author:OtsukaKojiK, pubmed-author:SueyoshiKenjiK, pubmed-author:TsunekaTakashiT, pubmed-author:UchiyamaKenjiK
pubmed:issnType	Print
pubmed:day	17
pubmed:volume	1106
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	36-42
pubmed:dateRevised	2009-1-15
pubmed:meshHeading	pubmed-meshheading:16443450-Electrophoresis, Capillary, pubmed-meshheading:16443450-Microscopy, pubmed-meshheading:16443450-Sensitivity and Specificity
pubmed:year	2006
pubmed:articleTitle	Toward million-fold sensitivity enhancement by sweeping in capillary electrophoresis combined with thermal lens microscopic detection using an interface chip.
pubmed:affiliation	Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Kyoto 615-8510, Japan. fkitagawa@mbox.kudpc.kyoto-u.ac.jp
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't