Source:http://linkedlifedata.com/resource/pubmed/id/16440985
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2006-1-30
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pubmed:abstractText |
A new synthesis of 6-amino-1-hydroxyethoxymethyl-4 (5H)-oxopyrazolo[3, 4-d]pyrimidine (4) has been mentioned. Compound 4 exhibited inhibition of amastigotes of Leishmania donovani to the extent of 89 % at 30 microg/mL, whereas iso-guanine analogue 5 had the inhibition only to the extent of 52.8% at 100 microg/mL in vitro. In hamster model the maximum inhibitory response for compound 4 against amastigotes multiplication was observed to be 94% at 50 mg/kg single dose for 5 consecutive days.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
1525-7770
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
55-60
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pubmed:meshHeading |
pubmed-meshheading:16440985-Animals,
pubmed-meshheading:16440985-Antiparasitic Agents,
pubmed-meshheading:16440985-Cricetinae,
pubmed-meshheading:16440985-Leishmania donovani,
pubmed-meshheading:16440985-Male,
pubmed-meshheading:16440985-Molecular Structure,
pubmed-meshheading:16440985-Pyrimidine Nucleosides
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pubmed:year |
2006
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pubmed:articleTitle |
Acyclic pyrazolo[3,4-d]pyrimidine nucleoside as potential leishmaniostatic agent.
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pubmed:affiliation |
Division of Medicinal & Process Chemistry, Central Drug Research Institute, Lucknow, India.
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pubmed:publicationType |
Journal Article
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