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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
|
| pubmed:dateCreated |
1992-9-10
|
| pubmed:abstractText |
The effect of ischaemia, either alone or after a single or multidose infusion of St Thomas' Hospital cardioplegia solution (ST), on endothelial function was studied by examining its influence on 5-Hydroxytryptamine- (5-HT-) and nitroglycerine- (GTN-) induced coronary vasodilation in the isolated rat heart. Eighty rat hearts were perfused on a modified Langendorff preparation. Thirty minutes of unprotected ischaemia (N = 16) abolished the vasodilatory response to 5-HT but maintained the response to GTN (expressed as % of the control value 5-HT, pre 45.0 +/- 3.5, post 2.3 +/- 3.2, GTN, pre 42.3 +/- 4.4, post 39.8 +/- 4.0). The increase in coronary flow induced by either agent was unaltered following 30 or 60 min of ischaemia protected by a single dose of ST (N = 16 in each). Ninety minutes of ischaemia preceded by a single infusion of ST (N = 16) markedly reduced the 5-HT response but maintained the vasodilation induced by GTN (5-HT, pre 37 +/- 2.6, post 6.9 +/- 2.6, GTN, pre 40.1 +/- 2.5, post 37 +/- 2.8). During 90 min of ischaemia, infusion of an additional dose of ST after 45 min (N = 8) or two extra doses every 30 min (N = 8) maintained the 5-HT-induced increase in coronary flow (pre 39.5 +/- 3.9, post 36.4 +/- 3.5). It can be concluded that coronary vascular endothelium is more susceptible to ischaemic damage when compared with vascular smooth muscle. This results in early loss of endothelium-dependent vasodilation. Multidose infusion of St Thomas' Hospital cardioplegia solution is superior to a single infusion in protecting endothelial function following prolonged cardiac ischaemia.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Bicarbonates,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium Chloride,
http://linkedlifedata.com/resource/pubmed/chemical/Cardioplegic Solutions,
http://linkedlifedata.com/resource/pubmed/chemical/Magnesium,
http://linkedlifedata.com/resource/pubmed/chemical/Nitroglycerin,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium Chloride,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium Chloride,
http://linkedlifedata.com/resource/pubmed/chemical/St. Thomas' Hospital cardioplegic...
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0195-668X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
13
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
976-80
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:1644091-Animals,
pubmed-meshheading:1644091-Bicarbonates,
pubmed-meshheading:1644091-Calcium Chloride,
pubmed-meshheading:1644091-Cardioplegic Solutions,
pubmed-meshheading:1644091-Coronary Circulation,
pubmed-meshheading:1644091-Coronary Disease,
pubmed-meshheading:1644091-Coronary Vessels,
pubmed-meshheading:1644091-Dose-Response Relationship, Drug,
pubmed-meshheading:1644091-Endothelium, Vascular,
pubmed-meshheading:1644091-Heart Arrest, Induced,
pubmed-meshheading:1644091-Magnesium,
pubmed-meshheading:1644091-Male,
pubmed-meshheading:1644091-Nitroglycerin,
pubmed-meshheading:1644091-Potassium Chloride,
pubmed-meshheading:1644091-Rats,
pubmed-meshheading:1644091-Rats, Inbred Strains,
pubmed-meshheading:1644091-Reperfusion Injury,
pubmed-meshheading:1644091-Sodium Chloride
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
Ischaemic endothelial dysfunction after single or multidose cardioplegia.
|
| pubmed:affiliation |
National Heart and Lung Institute, London, U.K.
|
| pubmed:publicationType |
Journal Article
|