16439700

Source:http://linkedlifedata.com/resource/pubmed/id/16439700

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0026809, umls-concept:C0221099, umls-concept:C0449258, umls-concept:C0917996
pubmed:issue	3
pubmed:dateCreated	2006-2-28
pubmed:abstractText	Subarachnoid hemorrhage caused by cerebral aneurysm rupture remains a life-threatening emergency despite advances in treatment. However, the mechanisms underlying aneurysm initiation, progression, and rupture remain unclear. We developed a method to induce experimental cerebral aneurysms in rats, monkeys, and mice. Interleukin-1beta (IL-1beta) is a key inflammatory mediator, and it is thought to be a promising target for the treatment of inflammatory diseases. In the present study, we examined the role of IL-1beta in cerebral aneurysm development.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0235266
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Caspase 1, http://linkedlifedata.com/resource/pubmed/chemical/DNA, Single-Stranded, http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1, http://linkedlifedata.com/resource/pubmed/chemical/RNA
pubmed:status	MEDLINE
pubmed:month	Mar
pubmed:issn	1524-4628
pubmed:author	pubmed-author:AokiTomohiroT, pubmed-author:HashimotoNobuoN, pubmed-author:MoriwakiTakuyaT, pubmed-author:NozakiKazuhikoK, pubmed-author:SadamasaNobutakeN, pubmed-author:TakagiYasushiY
pubmed:issnType	Electronic
pubmed:volume	37
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	900-5
pubmed:dateRevised	2006-11-15
pubmed:meshHeading	pubmed-meshheading:16439700-Aneurysm, pubmed-meshheading:16439700-Animals, pubmed-meshheading:16439700-Apoptosis, pubmed-meshheading:16439700-Caspase 1, pubmed-meshheading:16439700-Cerebrovascular Disorders, pubmed-meshheading:16439700-DNA, Single-Stranded, pubmed-meshheading:16439700-Disease Models, Animal, pubmed-meshheading:16439700-Disease Progression, pubmed-meshheading:16439700-Immunohistochemistry, pubmed-meshheading:16439700-In Situ Nick-End Labeling, pubmed-meshheading:16439700-Inflammation, pubmed-meshheading:16439700-Interleukin-1, pubmed-meshheading:16439700-Intracranial Aneurysm, pubmed-meshheading:16439700-Male, pubmed-meshheading:16439700-Mice, pubmed-meshheading:16439700-Mice, Inbred C57BL, pubmed-meshheading:16439700-Mice, Transgenic, pubmed-meshheading:16439700-Models, Statistical, pubmed-meshheading:16439700-RNA, pubmed-meshheading:16439700-Reverse Transcriptase Polymerase Chain Reaction, pubmed-meshheading:16439700-Time Factors
pubmed:year	2006
pubmed:articleTitle	Impaired progression of cerebral aneurysms in interleukin-1beta-deficient mice.
pubmed:affiliation	Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't