Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
2006-6-8
pubmed:abstractText
A new method for estimation of current-source density (CSD) from local field potentials is presented. This inverse CSD (iCSD) method is based on explicit inversion of the electrostatic forward solution and can be applied to data from multielectrode arrays with various geometries. Here, the method is applied to linear-array (laminar) electrode data. Three iCSD methods are considered: the CSD is assumed to have cylindrical symmetry and be (i) localized in infinitely thin discs, (ii) step-wise constant or (iii) continuous and smoothly varying (using cubic splines) in the vertical direction. For spatially confined CSD distributions the standard CSD method, involving a discrete double derivative, is seen in model calculations to give significant estimation errors when the lateral source dimension is comparable to the size of a cortical column (less than approximately 1 mm). Further, discontinuities in the extracellular conductivity are seen to potentially give sizable errors for even wider source distributions. The iCSD methods are seen to give excellent estimates when the correct lateral source dimension and spatial distribution of conductivity are incorporated. To illustrate the application to real data, iCSD estimates of stimulus-evoked responses measured with laminar electrodes in the rat somatosensory (barrel) cortex are compared to estimates from the standard CSD method.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0165-0270
pubmed:author
pubmed:issnType
Print
pubmed:day
30
pubmed:volume
154
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
116-33
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:16436298-Algorithms, pubmed-meshheading:16436298-Animals, pubmed-meshheading:16436298-Cerebrovascular Circulation, pubmed-meshheading:16436298-Data Interpretation, Statistical, pubmed-meshheading:16436298-Electric Conductivity, pubmed-meshheading:16436298-Electrophysiology, pubmed-meshheading:16436298-Extracellular Space, pubmed-meshheading:16436298-Male, pubmed-meshheading:16436298-Membrane Potentials, pubmed-meshheading:16436298-Microelectrodes, pubmed-meshheading:16436298-Models, Neurological, pubmed-meshheading:16436298-Models, Statistical, pubmed-meshheading:16436298-Neural Conduction, pubmed-meshheading:16436298-Neurons, pubmed-meshheading:16436298-Physical Stimulation, pubmed-meshheading:16436298-Rats, pubmed-meshheading:16436298-Rats, Sprague-Dawley, pubmed-meshheading:16436298-Somatosensory Cortex, pubmed-meshheading:16436298-Vibrissae
pubmed:year
2006
pubmed:articleTitle
Current-source density estimation based on inversion of electrostatic forward solution: effects of finite extent of neuronal activity and conductivity discontinuities.
pubmed:affiliation
Department of Mathematical Sciences and Technology, Norwegian University of Life Sciences, As.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural