Linked Life Data

16436284

Source:http://linkedlifedata.com/resource/pubmed/id/16436284

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2006-5-22
pubmed:abstractText
2,6-Diisopropylphenol (Propofol) is a short-acting intravenous anesthetic that is rapidly metabolized by glucuronidation and ring hydroxylation catalyzed by cytochrome P450. The goal of this research was to determine whether dietary monoterpene alcohols (MAs) could be used to prolong the anesthetic effect of propofol by inhibiting propofol metabolism in animals. Mice were injected intraperitoneally (i.p.) with MAs (100-200) mg/kg followed by the administration of 100 mg/kg propofol 40 min later via an i.p. injection. The time of the anesthesia of each mouse was recorded. It was found that (+/-)-borneol, (-)-carveol, trans-sobrerol, and menthol significantly extended the anesthetic effect of propofol (>3 times). The concentration of propofol in the mouse blood over time (up to 180 min) also increased in mice pre-treated with (-)-borneol, (-)-carveol, and trans-sobrerol. The volume of distribution of propofol decreased in the (-)-borneol (p<0.05), pre-treated group as compared to the propofol control group. Moreover, the maximum blood concentration of propofol and the concentration of propofol in the blood as indicated by the area under the curve were significantly increased in (-)-borneol and (-)-carveol pre-treated groups. Additional evidence using rat hepatocytes showed that (-)-borneol inhibited propofol glucuronidation whereas trans-sobrerol and (-)-carveol inhibited cytochrome P450 dependent microsomal aminopyrine N-demethylation. These results suggest that (-)-borneol extends propofol-induced anesthesia by inhibiting its glucuronidation in the mouse whereas trans-sobrerol (-)-carveol extends propofol-induced anesthesia by inhibiting P450 catalyzed propofol metabolism.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0024-3205
pubmed:author
pubmed:issnType
Print
pubmed:day
30
pubmed:volume
79
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
21-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:16436284-Alcohols, pubmed-meshheading:16436284-Aminopyrine N-Demethylase, pubmed-meshheading:16436284-Anesthesia, pubmed-meshheading:16436284-Anesthetics, Intravenous, pubmed-meshheading:16436284-Animals, pubmed-meshheading:16436284-Bornanes, pubmed-meshheading:16436284-Chromatography, High Pressure Liquid, pubmed-meshheading:16436284-Cytochrome P-450 Enzyme System, pubmed-meshheading:16436284-Dose-Response Relationship, Drug, pubmed-meshheading:16436284-Glucuronides, pubmed-meshheading:16436284-Hepatocytes, pubmed-meshheading:16436284-Liver, pubmed-meshheading:16436284-Male, pubmed-meshheading:16436284-Mice, pubmed-meshheading:16436284-Microsomes, Liver, pubmed-meshheading:16436284-Monoterpenes, pubmed-meshheading:16436284-Propofol, pubmed-meshheading:16436284-Rats, pubmed-meshheading:16436284-Rats, Sprague-Dawley, pubmed-meshheading:16436284-Terpenes
pubmed:year
2006
pubmed:articleTitle
Herbal monoterpene alcohols inhibit propofol metabolism and prolong anesthesia time.
pubmed:affiliation
Pharmaceutical Sciences Department, University of Toronto, 19 Russell Street, Toronto, Ontario, M5S 2S2, Canada.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't