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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2006-2-21
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pubmed:abstractText |
Peroxisome proliferator-activated receptor-gamma co-activator-1alpha (PPARGC1A) is a transcriptional co-activator with a central role in energy expenditure and glucose metabolism. Several studies have suggested that the common PPARGC1A polymorphism Gly482Ser may be associated with risk of type 2 diabetes, with conflicting results. To clarify the role of Gly482Ser in type 2 diabetes and related human metabolic phenotypes we genotyped this polymorphism in a case-control study and performed a meta-analysis of relevant published data.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0012-186X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
49
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
501-5
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:16435105-Blood Glucose,
pubmed-meshheading:16435105-Body Mass Index,
pubmed-meshheading:16435105-Diabetes Mellitus, Type 2,
pubmed-meshheading:16435105-Fasting,
pubmed-meshheading:16435105-Glycine,
pubmed-meshheading:16435105-Heat-Shock Proteins,
pubmed-meshheading:16435105-Humans,
pubmed-meshheading:16435105-Insulin,
pubmed-meshheading:16435105-Phenotype,
pubmed-meshheading:16435105-Polymorphism, Genetic,
pubmed-meshheading:16435105-Serine,
pubmed-meshheading:16435105-Transcription Factors
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pubmed:year |
2006
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pubmed:articleTitle |
Meta-analysis of the Gly482Ser variant in PPARGC1A in type 2 diabetes and related phenotypes.
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pubmed:affiliation |
The Wellcome Trust Sanger Institute, Metabolic Disease Group, The Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK. ib1@sanger.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Meta-Analysis
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