Linked Life Data

16434715

Source:http://linkedlifedata.com/resource/pubmed/id/16434715

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pubmed-article:16434715pubmed:abstractTextThe pneumococcal surface protein PspA, a cell-wall-associated surface protein, is a promising component for pneumococcal vaccines. In this study, the distribution of the PspA family was determined in a panel of invasive and clinically important pneumococcal isolates from adults over 50 years of age, collected between 1995 and 2002. One thousand eight hundred and forty-seven recent isolates from invasive pneumococcal disease were obtained from seven Western countries, together with clinical data. An ELISA-based serological method was standardized in order to determine the PspA family and clade distribution. Molecular tests were used when isolates were non-typable by ELISA (PspA family typing by PCR). Only 42 (2.3 %) isolates were non-typable by ELISA and PspA family typing by PCR was performed. Finally, 3 isolates were considered as non-pneumococcal and 1844 were classified as follows: 749 (40.6 %) were PspA family 1, 1078 (58.5 %) were PspA family 2, 13 (0.7 %) were PspA family 1 and 2 and 4 (0.2 %) remained non-typable. The cross-reactivity of antibodies to PspAs of different clades was confirmed. In conclusion, inclusion of PspA family 1 and family 2 in future pneumococcal vaccines would ensure broad coverage of pneumococcal strains infecting people over 50 years of age.lld:pubmed
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pubmed-article:16434715pubmed:pagination215-21lld:pubmed
pubmed-article:16434715pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:16434715pubmed:year2006lld:pubmed
pubmed-article:16434715pubmed:articleTitlePneumococcal surface protein A (PspA) family distribution among clinical isolates from adults over 50 years of age collected in seven countries.lld:pubmed
pubmed-article:16434715pubmed:affiliationDepartment of Microbiology, University of Alabama at Birmingham, BBRB 658, AL 35294, USA.lld:pubmed
pubmed-article:16434715pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:16434715pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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