Source:http://linkedlifedata.com/resource/pubmed/id/16434715
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
Pt 2
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pubmed:dateCreated |
2006-1-25
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pubmed:abstractText |
The pneumococcal surface protein PspA, a cell-wall-associated surface protein, is a promising component for pneumococcal vaccines. In this study, the distribution of the PspA family was determined in a panel of invasive and clinically important pneumococcal isolates from adults over 50 years of age, collected between 1995 and 2002. One thousand eight hundred and forty-seven recent isolates from invasive pneumococcal disease were obtained from seven Western countries, together with clinical data. An ELISA-based serological method was standardized in order to determine the PspA family and clade distribution. Molecular tests were used when isolates were non-typable by ELISA (PspA family typing by PCR). Only 42 (2.3 %) isolates were non-typable by ELISA and PspA family typing by PCR was performed. Finally, 3 isolates were considered as non-pneumococcal and 1844 were classified as follows: 749 (40.6 %) were PspA family 1, 1078 (58.5 %) were PspA family 2, 13 (0.7 %) were PspA family 1 and 2 and 4 (0.2 %) remained non-typable. The cross-reactivity of antibodies to PspAs of different clades was confirmed. In conclusion, inclusion of PspA family 1 and family 2 in future pneumococcal vaccines would ensure broad coverage of pneumococcal strains infecting people over 50 years of age.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0022-2615
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
55
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
215-21
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16434715-Aged,
pubmed-meshheading:16434715-Antibodies, Bacterial,
pubmed-meshheading:16434715-Australia,
pubmed-meshheading:16434715-Bacterial Proteins,
pubmed-meshheading:16434715-Canada,
pubmed-meshheading:16434715-Cross Reactions,
pubmed-meshheading:16434715-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:16434715-Europe,
pubmed-meshheading:16434715-Female,
pubmed-meshheading:16434715-Humans,
pubmed-meshheading:16434715-Male,
pubmed-meshheading:16434715-Middle Aged,
pubmed-meshheading:16434715-Pneumococcal Infections,
pubmed-meshheading:16434715-Polymerase Chain Reaction,
pubmed-meshheading:16434715-Streptococcus pneumoniae,
pubmed-meshheading:16434715-United States
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pubmed:year |
2006
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pubmed:articleTitle |
Pneumococcal surface protein A (PspA) family distribution among clinical isolates from adults over 50 years of age collected in seven countries.
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pubmed:affiliation |
Department of Microbiology, University of Alabama at Birmingham, BBRB 658, AL 35294, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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