Source:http://linkedlifedata.com/resource/pubmed/id/16434500
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rdf:type | |
lifeskim:mentions |
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0026809,
umls-concept:C0079904,
umls-concept:C0429403,
umls-concept:C0525129,
umls-concept:C0752063,
umls-concept:C1417708,
umls-concept:C1423613,
umls-concept:C1442161,
umls-concept:C1512409,
umls-concept:C1521801,
umls-concept:C1539081,
umls-concept:C1705525,
umls-concept:C1711351
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pubmed:issue |
2
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pubmed:dateCreated |
2006-3-10
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pubmed:abstractText |
Wy-14,643 (WY) is a hypolipidemic drug that induces hepatic peroxisome proliferation and tumors in rodents. We previously showed that peroxisome proliferators increase NF-kappaB DNA binding activity in rats, mice, and hepatoma cell lines, and that mice deficient in the p50 subunit of NF-kappaB had much lower cell proliferation in response to the peroxisome proliferator ciprofibrate. In this study we examined the promotion of hepatocarcinogenesis by WY in the p50 knockout (-/-) mice. The p50 -/- and wild type mice were first administered diethylnitrosamine (DEN) as an initiating agent. Mice were then fed a control diet or a diet containing 0.05% WY for 38 weeks. Wild-type mice receiving DEN only developed a low incidence of tumors, and the majority of wild-type mice receiving both DEN and WY developed tumors. However, no tumors were seen in any of the p50 -/- mice. Cell proliferation and apoptosis were measured in hepatocytes by BrdU labeling and the TUNEL assay, respectively. Treatment with DEN + WY increased both cell proliferation and apoptosis in both the wild-type and p50 -/- mice; DEN treatment alone has no effect. In the DEN/WY-treated mice, cell proliferation and apoptosis were slightly lower in the p50 -/- mice than in the wild-type mice. These data demonstrate that NF-kappaB is involved in the promotion of hepatic tumors by the peroxisome proliferator WY; however, the difference in tumor incidence could not be attributed to alterations in either cell proliferation or apoptosis.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acyl-CoA Oxidase,
http://linkedlifedata.com/resource/pubmed/chemical/Carcinogens,
http://linkedlifedata.com/resource/pubmed/chemical/Diethylnitrosamine,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B p50 Subunit,
http://linkedlifedata.com/resource/pubmed/chemical/Peroxisome Proliferators,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrimidines,
http://linkedlifedata.com/resource/pubmed/chemical/pirinixic acid
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1096-6080
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
90
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
331-6
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pubmed:dateRevised |
2010-9-17
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pubmed:meshHeading |
pubmed-meshheading:16434500-Acyl-CoA Oxidase,
pubmed-meshheading:16434500-Adenoma, Liver Cell,
pubmed-meshheading:16434500-Animals,
pubmed-meshheading:16434500-Apoptosis,
pubmed-meshheading:16434500-Carcinogens,
pubmed-meshheading:16434500-Cell Proliferation,
pubmed-meshheading:16434500-Diethylnitrosamine,
pubmed-meshheading:16434500-Liver,
pubmed-meshheading:16434500-Liver Neoplasms, Experimental,
pubmed-meshheading:16434500-Mice,
pubmed-meshheading:16434500-Mice, Inbred Strains,
pubmed-meshheading:16434500-Mice, Knockout,
pubmed-meshheading:16434500-NF-kappa B p50 Subunit,
pubmed-meshheading:16434500-Peroxisome Proliferators,
pubmed-meshheading:16434500-Pyrimidines
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pubmed:year |
2006
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pubmed:articleTitle |
Inhibition of hepatocarcinogenesis by the deletion of the p50 subunit of NF-kappaB in mice administered the peroxisome proliferator Wy-14,643.
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pubmed:affiliation |
Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, Kentucky 40506, USA. hglauert@uky.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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