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rdf:type |
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lifeskim:mentions |
|
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pubmed:issue |
10
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pubmed:dateCreated |
2006-4-4
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|
pubmed:abstractText |
Suberoylanilide hydroxamic acid (SAHA), an inhibitor of histone deacetylase, is used in clinical trials for a variety of advanced cancers. Twelve new analogs of SAHA were synthesized and tested as in vitro inhibitors of isolated histone deacetylases (HDACS) and in vivo inhibitors of interferon regulated transcriptional responses (a marker for HDAC activity). The analogs containing an alpha-mercaptoketone or an alpha-thioacetoxyketone were more potent than SAHA in both assays.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0968-0896
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3320-9
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:16434199-Cells, Cultured,
pubmed-meshheading:16434199-Drug Design,
pubmed-meshheading:16434199-Drug Evaluation, Preclinical,
pubmed-meshheading:16434199-Enzyme Inhibitors,
pubmed-meshheading:16434199-Genes, Reporter,
pubmed-meshheading:16434199-HeLa Cells,
pubmed-meshheading:16434199-Histone Deacetylase Inhibitors,
pubmed-meshheading:16434199-Histone Deacetylases,
pubmed-meshheading:16434199-Humans,
pubmed-meshheading:16434199-Hydroxamic Acids,
pubmed-meshheading:16434199-Ketones,
pubmed-meshheading:16434199-Ligands,
pubmed-meshheading:16434199-Molecular Structure,
pubmed-meshheading:16434199-Sulfhydryl Compounds,
pubmed-meshheading:16434199-Transcription, Genetic
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|
pubmed:year |
2006
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pubmed:articleTitle |
Carbonyl- and sulfur-containing analogs of suberoylanilide hydroxamic acid: Potent inhibition of histone deacetylases.
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|
pubmed:affiliation |
Department of Chemistry, Northwestern University, Evanston, IL 60208-3113, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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