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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
15
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pubmed:dateCreated |
2006-3-20
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pubmed:abstractText |
Heterologous prime-boost immunisation with RTS,S/AS02A and the poxvirus MVA-CS was evaluated in 18 healthy malaria-naïve subjects in Oxford. Both priming with RTS,S and boosting MVA-CS, and the reverse, were found to be safe and well tolerated. T cell responses as measured by IFN-gamma ex vivo ELISPOT were induced, but the responses were low to moderate in both groups, with heterologous boosting yielding only small increments in T cell immunogenicity and no increased antibody response. Protection against 3D7 Plasmodium falciparum sporozoite challenge 4 weeks after the final vaccination was equal for both regimens at 33% (95% C.I. 4.3-77.7%), with one subject remaining fully protected on rechallenge at 5 months.
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pubmed:grant |
|
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pubmed:language |
eng
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pubmed:journal |
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|
pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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|
pubmed:issn |
0264-410X
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pubmed:author |
pubmed-author:AndrewsLauraL,
pubmed-author:BejonPhilipP,
pubmed-author:BerthoudTamaraT,
pubmed-author:ButcherGeoffreyG,
pubmed-author:CohenJoeJ,
pubmed-author:DubovskyFilipF,
pubmed-author:DunachieSusanna JSJ,
pubmed-author:GilbertSarah CSC,
pubmed-author:HeppnerD GrayDGJr,
pubmed-author:HillAdrian V SAV,
pubmed-author:KeatingSheila MSM,
pubmed-author:LeachAmandaA,
pubmed-author:MorisPhilippeP,
pubmed-author:PoultonIanI,
pubmed-author:SchneiderJoergJ,
pubmed-author:SindenRobert ERE,
pubmed-author:TierneyEvelineE,
pubmed-author:TornieporthNadiaN,
pubmed-author:VuolaJenni MJM,
pubmed-author:WaltherMichaelM,
pubmed-author:WatkinsKatherineK,
pubmed-author:WebsterDaniel PDP,
pubmed-author:WilliamsJackJ
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pubmed:issnType |
Print
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|
pubmed:day |
5
|
|
pubmed:volume |
24
|
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pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
2850-9
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:16434127-Adolescent,
pubmed-meshheading:16434127-Adult,
pubmed-meshheading:16434127-Antibodies, Protozoan,
pubmed-meshheading:16434127-Female,
pubmed-meshheading:16434127-Humans,
pubmed-meshheading:16434127-Immunization, Secondary,
pubmed-meshheading:16434127-Interferon-gamma,
pubmed-meshheading:16434127-Malaria,
pubmed-meshheading:16434127-Malaria Vaccines,
pubmed-meshheading:16434127-Male,
pubmed-meshheading:16434127-Middle Aged,
pubmed-meshheading:16434127-T-Lymphocytes,
pubmed-meshheading:16434127-Vaccinia virus
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pubmed:year |
2006
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|
pubmed:articleTitle |
A clinical trial of prime-boost immunisation with the candidate malaria vaccines RTS,S/AS02A and MVA-CS.
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pubmed:affiliation |
Centre for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Churchill Hospital, Oxford OX3 7LJ, UK. susie.dunachie@ndm.ox.ac.uk
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pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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