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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2006-2-1
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pubmed:abstractText |
PTEN (phosphatase and tensin homolog deleted on chromosome 10) is a potent tumor suppressor gene frequently mutated in human prostate cancers. Deletion of Pten in a murine model of prostate cancer recapitulates the disease progression seen in humans. Using defined cell lineage markers, we demonstrate that PTEN negatively regulates p63-positive prostatic basal cell proliferation without blocking differentiation. Concomitant with basal cell proliferation is the expansion of a prostate stem/progenitor-like subpopulation as evidenced by the progressive increase of stem cell antigen-1 (Sca-1)- and BCL-2-positive cells. This observation provides strong evidence that basal cell proliferation can be an initiating event for precancerous lesions. Sca-1(+) and BCL-2(+) progenitors may serve as cancer-initiating cells in this model.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16432235-10361549,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16432235-10453283,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16432235-10735013,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16432235-10769197,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16432235-11106548,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16432235-11231059,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16432235-11309275,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16432235-11597556,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16432235-11691952,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16432235-11776479,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16432235-11900250,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16432235-12052957,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16432235-12082083,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16432235-12204531,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16432235-12218572,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16432235-12393817,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16432235-12496358,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16432235-12909713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16432235-14522255,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16432235-14668450,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16432235-15108804,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16432235-15163300,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16432235-15226377,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16432235-15289813,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16432235-15306667,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16432235-15507204,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16432235-15507213,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16432235-15607956,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16432235-15607963,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16432235-15860580,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16432235-15899981,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16432235-16051706,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16432235-16373498,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16432235-3684783,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16432235-681909,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16432235-9736039,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16432235-9774969,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16432235-9817389
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Bromodeoxyuridine,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Ki-67 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/PTEN Phosphohydrolase,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/TP63 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Trp63 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
31
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pubmed:volume |
103
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1480-5
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:16432235-Humans,
pubmed-meshheading:16432235-Animals,
pubmed-meshheading:16432235-Mice,
pubmed-meshheading:16432235-Neoplasms,
pubmed-meshheading:16432235-Prostatic Neoplasms,
pubmed-meshheading:16432235-Microscopy, Fluorescence,
pubmed-meshheading:16432235-Male,
pubmed-meshheading:16432235-Kinetics,
pubmed-meshheading:16432235-Cell Nucleus,
pubmed-meshheading:16432235-Time Factors,
pubmed-meshheading:16432235-Disease Models, Animal,
pubmed-meshheading:16432235-Cell Differentiation,
pubmed-meshheading:16432235-Bromodeoxyuridine,
pubmed-meshheading:16432235-Disease Progression,
pubmed-meshheading:16432235-Cell Separation
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