Linked Life Data

16430376

Source:http://linkedlifedata.com/resource/pubmed/id/16430376

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2006-1-24
pubmed:abstractText
Isoflurane is commonly used in experimental traumatic brain injury (TBI), both before and early after injury, yet it is rarely used clinically. Narcotics and benzodiazepines are frequently used after injury in clinical TBI. We compared seven anesthetic/sedative agents applied after injury in the controlled cortical impact model: diazepam, fentanyl, isoflurane, ketamine, morphine, pentobarbital, and propofol. Our objective was to provide insight into the relative degrees of neuroprotection provided by these agents in a standard model of TBI. We hypothesized that the choice of anesthetic/sedative early after experimental TBI critically impacts outcome and that the agents most commonly used clinically may be less neuroprotective than isoflurane. Rats treated with isoflurane had the best cognitive recovery (p < 0.05) and hippocampal neuronal survival (p < 0.05). Conversely, rats treated with ketamine had the most hippocampal neuronal death (p < 0.05). Morphine or propofol, two agents commonly used clinically, were associated with the poorest motor function on post-trauma day 1-5 (p < 0.05). Our data support beneficial effects of isoflurane early after experimental TBI. Our data suggest that the early post-TBI use of isoflurane, despite practical logistical issues, could potentially provide clinical benefits in TBI--versus other commonly used sedatives or analgesics. Furthermore, the choice of post-injury sedation and analgesia could have important implications on attempts to translate novel therapies from bench to field or bedside.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0897-7151
pubmed:author
pubmed:issnType
Print
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
97-108
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:16430376-Anesthetics, pubmed-meshheading:16430376-Animals, pubmed-meshheading:16430376-Brain, pubmed-meshheading:16430376-Brain Injuries, pubmed-meshheading:16430376-Cell Survival, pubmed-meshheading:16430376-Cognition Disorders, pubmed-meshheading:16430376-Diazepam, pubmed-meshheading:16430376-Disease Models, Animal, pubmed-meshheading:16430376-Fentanyl, pubmed-meshheading:16430376-Hippocampus, pubmed-meshheading:16430376-Hypnotics and Sedatives, pubmed-meshheading:16430376-Isoflurane, pubmed-meshheading:16430376-Ketamine, pubmed-meshheading:16430376-Male, pubmed-meshheading:16430376-Morphine, pubmed-meshheading:16430376-Neuroprotective Agents, pubmed-meshheading:16430376-Pentobarbital, pubmed-meshheading:16430376-Propofol, pubmed-meshheading:16430376-Rats, pubmed-meshheading:16430376-Rats, Sprague-Dawley
pubmed:year
2006
pubmed:articleTitle
Comparison of seven anesthetic agents on outcome after experimental traumatic brain injury in adult, male rats.
pubmed:affiliation
Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. kim.statler@hsc.utah.edu
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural