Linked Life Data

16427690

Source:http://linkedlifedata.com/resource/pubmed/id/16427690

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2006-3-14
pubmed:abstractText
Broadband white noise exposure (100 dB) in wistar strain male albino rats significantly increased the levels of dopamine (DA), serotonin (5-HT) and 5-HT turnover in many of the discrete brain regions (cerebral cortex, cerebellum, hypothalamus, hippocampus, pons-medulla and corpus striatum) during sub-chronic noise exposure (4 h daily for 15 days). In acute (4 h for 1 day) and chronic noise exposures (4 h daily for 30 days) the levels were significantly altered only in certain regions. The turnover study of serotonin clearly indicates that neurotransmitter level alone cannot be an indicator, as in some brain regions the rate of synthesis matched with the degradation in order to maintain the normal levels. The intraperitoneal administration of 70% ethanolic extract of Ocimum sanctum(OS) at the dosage of 100 mg/kg body weight to animals subjected to noise exposure has prevented the noise induced increase in neurotransmitter levels without affecting the normal levels. This indicates that OS can be a probable herbal remedy for noise induced biogenic amine alterations.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0091-3057
pubmed:author
pubmed:issnType
Print
pubmed:volume
83
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
67-75
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Biogenic amine changes in brain regions and attenuating action of Ocimum sanctumin noise exposure.
pubmed:affiliation
Department of Physiology, ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai 600 113, India. drjsamson@hotmail.com
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't