| pubmed-article:16426643 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16426643 | lifeskim:mentions | umls-concept:C0032961 | lld:lifeskim |
| pubmed-article:16426643 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:16426643 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:16426643 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:16426643 | lifeskim:mentions | umls-concept:C0014180 | lld:lifeskim |
| pubmed-article:16426643 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:16426643 | lifeskim:mentions | umls-concept:C0040690 | lld:lifeskim |
| pubmed-article:16426643 | lifeskim:mentions | umls-concept:C0950151 | lld:lifeskim |
| pubmed-article:16426643 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:16426643 | pubmed:issue | 23 | lld:pubmed |
| pubmed-article:16426643 | pubmed:dateCreated | 2006-4-24 | lld:pubmed |
| pubmed-article:16426643 | pubmed:abstractText | Roles of transforming growth factor-beta (TGF-beta) receptor types I (TbetaRI) and II (TbetaRII) during the estrous cycle and implantation of rodents are currently unclear. In the present study, the spatial and temporal expressions of TbetaRI and TbetaRII in rat endometrium during the estrous cycle, pre-, and peri-implantation were examined using in situ hybridization and semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR). With in situ hybridization, TbetaRI and TbetaRII were expressed at weak levels in rat endometrium during the estrous cycle. During pre-implantation, both receptors were expressed in the luminal epithelium and glandular epithelium on Days 0.5 and 1.5 of pregnancy, but were down-regulated on Days 2.5 and 3.5. During peri-implantation, both TGF-beta receptors were localized in the luminal epithelium and subepithelial stroma to facilitate attachment reaction and trophoblast invasion. They were highly expressed on Day 4.5, whereas were down-regulated on Days 5.5 and 6.5. Semi-quantitative RT-PCR analysis confirmed the data obtained by in situ hybridization. These results suggest that during pre-implantation, both TGF-beta receptors are functional in the proliferation of endometrial epithelial cells. During peri-implantation, both TGF-beta receptors play important roles during the onset of the uterine receptivity and the attachment reaction. TGF-beta signaling is down-regulated when trophoblast invasion begins. | lld:pubmed |
| pubmed-article:16426643 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16426643 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16426643 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16426643 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16426643 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16426643 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16426643 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16426643 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16426643 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16426643 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16426643 | pubmed:month | May | lld:pubmed |
| pubmed-article:16426643 | pubmed:issn | 0024-3205 | lld:pubmed |
| pubmed-article:16426643 | pubmed:author | pubmed-author:ZhuChengC | lld:pubmed |
| pubmed-article:16426643 | pubmed:author | pubmed-author:DongQianQ | lld:pubmed |
| pubmed-article:16426643 | pubmed:author | pubmed-author:ZhangXuanX | lld:pubmed |
| pubmed-article:16426643 | pubmed:author | pubmed-author:WangHong-MeiH... | lld:pubmed |
| pubmed-article:16426643 | pubmed:author | pubmed-author:LinHai-YanHY | lld:pubmed |
| pubmed-article:16426643 | pubmed:author | pubmed-author:LiuGuo-YiGY | lld:pubmed |
| pubmed-article:16426643 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16426643 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:16426643 | pubmed:volume | 78 | lld:pubmed |
| pubmed-article:16426643 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16426643 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16426643 | pubmed:pagination | 2669-75 | lld:pubmed |
| pubmed-article:16426643 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:16426643 | pubmed:meshHeading | pubmed-meshheading:16426643... | lld:pubmed |
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| pubmed-article:16426643 | pubmed:meshHeading | pubmed-meshheading:16426643... | lld:pubmed |
| pubmed-article:16426643 | pubmed:meshHeading | pubmed-meshheading:16426643... | lld:pubmed |
| pubmed-article:16426643 | pubmed:meshHeading | pubmed-meshheading:16426643... | lld:pubmed |
| pubmed-article:16426643 | pubmed:meshHeading | pubmed-meshheading:16426643... | lld:pubmed |
| pubmed-article:16426643 | pubmed:meshHeading | pubmed-meshheading:16426643... | lld:pubmed |
| pubmed-article:16426643 | pubmed:meshHeading | pubmed-meshheading:16426643... | lld:pubmed |
| pubmed-article:16426643 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16426643 | pubmed:articleTitle | Gene expression of transforming growth factor-beta receptors types I and II in rat endometrium during the estrous cycle and early pregnancy. | lld:pubmed |
| pubmed-article:16426643 | pubmed:affiliation | State Key Laboratory of Reproductive Biology, Institute of Zoology, the Chinese Academy of Sciences, 25 Bei Si Huan Xi Lu, Haidian District, Beijing 100080, PR China. | lld:pubmed |
| pubmed-article:16426643 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16426643 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:29591 | entrezgene:pubmed | pubmed-article:16426643 | lld:entrezgene |
| entrez-gene:81810 | entrezgene:pubmed | pubmed-article:16426643 | lld:entrezgene |
